NDLI: Multiwall carbon nanotube-modified electrode as a nanosensor for electrochemical studies and stripping voltammetric determination of an antimalarial drug

Content Provider	Royal Society of Chemistry (RSC)
Author	Ghoreishi, Sayed Mehdi Attaran, Abdol Mohammad Amin, Atiyeh Moqadam Khoobi, Asma
Copyright Year	2015
Abstract	A sensitive electrochemical method based on adsorptive stripping differential pulse voltammetry (AdSDPV) developed for the determination of an antimalarial drug, hydroxychloroquine (HCQ), using a multi-walled carbon nanotube (MWCNTs)-modified carbon paste electrode (MWCNTs/CPE). The modified nanosensor due to its enhanced conductivity showed a very large current response from the electroactive substrate. The modified electrode was characterized by different methods such as scanning electron microscopy (SEM) and cyclic voltammetry (CV). Also, some techniques including CV, chronoamperometry (CHA) and chronocoulometry (CHC) were used for electrochemical studies of HCQ. It was observed that by employing MWCNTs/CPE, a 4-fold enhancement in the HCQ signal was observed as compared to the carbon paste electrode (MWCNTs/CPE). Under the optimized conditions, the differential pulse voltammetric peak current was proportional to the HCQ concentration in the range of 5.7 × 10−8 M to 1 × 10−4 M with a detection limit (S/N = 3) of 6.0 nM. The analytical applications of the modified sensor were demonstrated by estimating HCQ in pharmaceutical formulations and biological fluids. Also, the modified electrode showed good reproducibility, long-term stability and anti-fouling effects.
Starting Page	14407
Ending Page	14415
Page Count	9
File Format	HTM / HTML PDF
ISSN	20462069
Volume Number	5
Issue Number	19
Journal	RSC Advances
DOI	10.1039/c4ra16357e
Language	English
Publisher	Royal Society of Chemistry
Access Restriction	Open
Subject Keyword	Carbon nanotube Cyclic voltammetry Hydroxychloroquine Electrode Electrochemistry Carbon paste electrode Chronoamperometry Antimalarial medication Nanosensor Scanning electron microscope Differential pulse voltammetry
Content Type	Text
Resource Type	Article
Subject	Chemistry Chemical Engineering

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