Please wait, while we are loading the content...
Please wait, while we are loading the content...
| Content Provider | Royal Society of Chemistry (RSC) |
|---|---|
| Author | Zhang, Ai-hua Jiao, Guo-zheng Sun, Hui Sun, Wen-jun Wang, Xi-jun |
| Copyright Year | 2013 |
| Abstract | Metabolomics is a powerful new technology that allows for the assessment of global low-molecular-weight metabolites in a biological system. It has shown great potential in biomarker discovery and, in particular, has renewed the interest in metabolism across biology and medicine. Recent development of metabolomics biomarkers and pathways for trajectory analysis remains challenging. Here, metabolomics techniques are the assessment of endogenous metabolites and may provide additional insights into carbon tetrachloride-induced liver injury. Ultra-performance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry (UPLC/MS) coupled with pattern recognition methods were carried out to obtain comprehensive metabolomics profiling and pathways of large biological data sets. Analysis of metabolic trajectory data indicated that primary bile acid biosynthesis, riboflavin metabolism, and tryptophan metabolism pathways were acutely perturbed, and 15 differential metabolites were identified. More importantly, the results indicate these ions in the positive mode as potential biomarkers of liver injury. Network construction has led to the integration of metabolites associated with the multiple perturbation pathways. Our findings suggest that the robust metabolomics method is promising to analyze and evaluate the trajectory of induced liver injury. |
| Starting Page | 5294 |
| Ending Page | 5301 |
| Page Count | 8 |
| File Format | HTM / HTML PDF |
| ISSN | 17599660 |
| Volume Number | 5 |
| Issue Number | 19 |
| Journal | Analytical Methods |
| DOI | 10.1039/c3ay40578h |
| Language | English |
| Publisher | Royal Society of Chemistry |
| Access Restriction | Open |
| Subject Keyword | Metabolomics Biomarker Acid Liver Electrospray ionization Riboflavin Tryptophan Pattern recognition Metabolism High-performance liquid chromatography Carbon Time-of-flight mass spectrometry Ionization Molecular biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Analytical Chemistry Engineering Chemical Engineering |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|