NDLI: Dynamic and flexible H3K9me3 bridging via HP1β dimerization establishes a plastic state of condensed chromatin

Content Provider	PubMed Central
Author	Hiragami-hamada, Kyoko Soeroes, Szabolcs Nikolov, Miroslav Wilkins, Bryan Kreuz, Sarah Chen, Carol De, La Rosa-velÃ¡zquez Inti A. Michael, Zenn Hans Kost, Nils Pohl, Wiebke Chernev, Aleksandar Schwarzer, Dirk Thomas, Jenuwein Lorincz, Matthew Zimmermann, Bastian Walla, Peter Jomo Neumann, Heinz Tuncay, Baubec Urlaub, Henning Wolfgang, Fischle
Copyright Year	2016
Abstract	Histone H3 trimethylation of lysine 9 (H3K9me3) and proteins of the heterochromatin protein 1 (HP1) family are hallmarks of heterochromatin, a state of compacted DNA essential for genome stability and long-term transcriptional silencing. The mechanisms by which H3K9me3 and HP1 contribute to chromatin condensation have been speculative and controversial. Here we demonstrate that human HP1β is a prototypic HP1 protein exemplifying most basal chromatin binding and effects. These are caused by dimeric and dynamic interaction with highly enriched H3K9me3 and are modulated by various electrostatic interfaces. HP1β bridges condensed chromatin, which we postulate stabilizes the compacted state. In agreement, HP1β genome-wide localization follows H3K9me3-enrichment and artificial bridging of chromatin fibres is sufficient for maintaining cellular heterochromatic conformation. Overall, our findings define a fundamental mechanism for chromatin higher order structural changes caused by HP1 proteins, which might contribute to the plastic nature of condensed chromatin.
Related Links	http://dx.doi.org/10.1038/ncomms11310
Starting Page	11310
File Format	PDF
ISSN	20411723
e-ISSN	20411723
Journal	Nature Communications
Volume Number	7
Language	English
Publisher	Nature Publishing Group
Publisher Date	2016-04-19
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Chemistry Physics and Astronomy Biochemistry, Genetics and Molecular Biology

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