NDLI: Genomic insights into the Ixodes scapularis tick vector of Lyme disease

Content Provider	PubMed Central
Author	Monika, Gulia-nuss Nuss, Andrew B. Meyer, Jason M. Sonenshine, Daniel E. Roe, R. Michael Waterhouse, Robert M. Sattelle, David B. Fuente, José De La Ribeiro, Jose M. Karine, Megy Jyothi, Thimmapuram Miller, Jason R. Walenz, Brian P. Koren, Sergey Hostetler, Jessica B. Thiagarajan, Mathangi Joardar, Vinita S. Hannick, Linda I. Bidwell, Shelby Hammond, Martin P. Young, Sarah Zeng, Qiandong Abrudan, Jenica L. Almeida, Francisca C. Nieves, Ayllón Bhide, Ketaki Bissinger, Brooke W. Elena, Bonzon-kulichenko Buckingham, Steven D. Caffrey, Daniel R. Caimano, Melissa J. Croset, Vincent Driscoll, Timothy Gilbert, Don Gillespie, Joseph J. Giraldo-calderón, Gloria I. Grabowski, Jeffrey M. Jiang, David Khalil, Sayed M. S. Kim, Donghun Kocan, Katherine M. Koči, Juraj Kuhn, Richard J. Kurtti, Timothy J. Lees, Kristin Lang, Emma G. Kennedy, Ryan C. Kwon, Hyeogsun Perera, Rushika Qi, Yumin Radolf, Justin D. Sakamoto, Joyce M. Alejandro, Sánchez-gracia Severo, Maiara S. Silverman, Neal Šimo, Ladislav Tojo, Marta Cristian, Tornador Zee, Janice P. Van Vázquez, Jesús Vieira, Filipe G. Villar, Margarita Wespiser, Adam R. Yang, Yunlong Zhu, Jiwei Peter, Arensburger Pietrantonio, Patricia V. Barker, Stephen C. Shao, Renfu Zdobnov, Evgeny M. Hauser, Frank Grimmelikhuijzen, Cornelis J. P. Park, Yoonseong Rozas, Julio Benton, Richard Pedra, Joao H. F. Nelson, David R. Unger, Maria F. Tubio, Jose M. C. Tu, Zhijian Robertson, Hugh M. Shumway, Martin Sutton, Granger Wortman, Jennifer R. Lawson, Daniel Wikel, Stephen K. Nene, Vishvanath M. Fraser, Claire M. Collins, Frank H. Birren, Bruce Nelson, Karen E. Caler, Elisabet Hill, Catherine A.
Copyright Year	2016
Abstract	Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic anaplasmosis, babesiosis and other diseases. The large genome reflects accumulation of repetitive DNA, new lineages of retro-transposons, and gene architecture patterns resembling ancient metazoans rather than pancrustaceans. Annotation of scaffolds representing ∼57% of the genome, reveals 20,486 protein-coding genes and expansions of gene families associated with tick–host interactions. We report insights from genome analyses into parasitic processes unique to ticks, including host ‘questing', prolonged feeding, cuticle synthesis, blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenesis and prolonged off-host survival. We identify proteins associated with the agent of human granulocytic anaplasmosis, an emerging disease, and the encephalitis-causing Langat virus, and a population structure correlated to life-history traits and transmission of the Lyme disease agent.
Related Links	http://dx.doi.org/10.1038/ncomms10507
Starting Page	10507
File Format	PDF
ISSN	20411723
e-ISSN	20411723
Journal	Nature Communications
Volume Number	7
Language	English
Publisher	Nature Publishing Group
Publisher Date	2016-02-01
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Physics and Astronomy(all) Chemistry(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Chemistry Physics and Astronomy Biochemistry, Genetics and Molecular Biology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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