NDLI: Effects of Selenylation Modification on Antioxidative Activities of Schisandra chinensis Polysaccharide

Content Provider	PubMed Central
Author	Yue, Chanjuan Chen, Jin Hou, Ranran Liu, Jie Li, Xiuping Gao, Zhenzhen Liu, Cui Wang, Deyun Lu, Yu Li, Hongquan Hu, Yuanliang
Editor	Acharya, Krishnendu
Copyright Year	2015
Abstract	The selenylation modification of Schisandra chinensis polysaccharide (SCP) was conducted by the HNO3–Na2SeO3 method respectively under nine conditions according to L9(34) orthogonal design. Nine selenizing SCPs, sSCP1–sSCP9, were obtained, and their antioxidant activities were compared. In vitro test, the free radical-scavenging rates of nine sSCPs were determined for DPPH., .OH and ABTS+. sSCP1 presented the most significant effect, and could inhibit the nonenzymatic protein glycation. In vivo test, 14-day-old chickens were injected respectively with sSCP1 and SCP, the serum contents of CAT, SOD and MDA were determined. The result showed that as compared with the SCP group, the SOD and CAT activities were significantly or numerically raised and MDA content was significantly or numerically lowered in the sSCP1 group. These results indicate that selenylation modification can significantly enhance the antioxidant and antiglycative activity of SCP in vitro or in vivo. sSCP1 possesses the best efficacy and its modification conditions can be as optimal modification conditions that were 200 mg of Na2SeO3 for 500 mg of SCP, reaction temperature of 50°C and reaction time of 6 h.
Related Links	http://dx.doi.org/10.1371/journal.pone.0134363
Starting Page	134363
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	7
Volume Number	10
Language	English
Publisher	Public Library of Science
Publisher Date	2015-07-31
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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