NDLI: The Esg Gene Is Involved in Nicotine Sensitivity in Drosophila melanogaster

Content Provider	PubMed Central
Author	Sanchez-díaz, Iván Fernando, Rosales-bravo Luis, Reyes-taboada José Covarrubias, Alejandra A. Verónica, Narvaez-padilla Reynaud, Enrique
Editor	Roman, Gregg
Copyright Year	2015
Abstract	In humans, there is a strong correlation between sensitivity to substances of abuse and addiction risk. This differential tolerance to drugs has a strong genetic component. The identification of human genetic factors that alter drug tolerance has been a difficult task. For this reason and taking advantage of the fact that Drosophila responds similarly to humans to many drugs, and that genetically it has a high degree of homology (sharing at least 70% of genes known to be involved in human genetic diseases), we looked for genes in Drosophila that altered their nicotine sensitivity. We developed an instantaneous nicotine vaporization technique that exposed flies in a reproducible way. The amount of nicotine sufficient to “knock out” half of control flies for 30 minutes was determined and this parameter was defined as Half Recovery Time (HRT). Two fly lines, L4 and L70, whose HRT was significantly longer than control´s were identified. The L4 insertion is a loss of function allele of the transcriptional factor escargot (esg), whereas L70 insertion causes miss-expression of the microRNA cluster miR-310-311-312-313 (miR-310c ). In this work, we demonstrate that esg loss of function induces nicotine sensitivity possibly by altering development of sensory organs and neurons in the medial section of the thoracoabdominal ganglion. The ectopic expression of the miR-310c also induces nicotine sensitivity by lowering Esg levels thus disrupting sensory organs and possibly to the modulation of other miR-310c targets.
Related Links	http://dx.doi.org/10.1371/journal.pone.0133956
Starting Page	133956
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	7
Volume Number	10
Language	English
Publisher	Public Library of Science
Publisher Date	2015-07-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

2mit, an Intronic Gene of Drosophila melanogaster timeless2, Is Involved in Behavioral Plasticity

The raspberry Gene Is Involved in the Regulation of the Cellular Immune Response in Drosophila melanogaster

Burkholderia thailandensis Is Virulent in Drosophila melanogaster

SETDB1 Is Involved in Postembryonic DNA Methylation and Gene Silencing in Drosophila

The Drosophila melanogaster methuselah Gene: A Novel Gene with Ancient Functions

Dopamine Modulates Metabolic Rate and Temperature Sensitivity in Drosophila melanogaster

Proteomic Characterization of Inbreeding-Related Cold Sensitivity in Drosophila melanogaster

On the Evolution of Yeti, a Drosophila melanogaster Heterochromatin Gene

The Unique GGA Clathrin Adaptor of Drosophila melanogaster Is Not Essential

The Esg Gene Is Involved in Nicotine Sensitivity in Drosophila melanogaster

Similar Documents

2mit, an Intronic Gene of Drosophila melanogaster timeless2, Is Involved in Behavioral Plasticity

The raspberry Gene Is Involved in the Regulation of the Cellular Immune Response in Drosophila melanogaster

Burkholderia thailandensis Is Virulent in Drosophila melanogaster

SETDB1 Is Involved in Postembryonic DNA Methylation and Gene Silencing in Drosophila

The Drosophila melanogaster methuselah Gene: A Novel Gene with Ancient Functions

Dopamine Modulates Metabolic Rate and Temperature Sensitivity in Drosophila melanogaster

Proteomic Characterization of Inbreeding-Related Cold Sensitivity in Drosophila melanogaster

On the Evolution of Yeti, a Drosophila melanogaster Heterochromatin Gene

The Unique GGA Clathrin Adaptor of Drosophila melanogaster Is Not Essential

The Esg Gene Is Involved in Nicotine Sensitivity in Drosophila melanogaster