NDLI: Hypoxia Up-Regulates Galectin-3 in Mammary Tumor Progression and Metastasis

Content Provider	PubMed Central
Author	Oliveira, Joana T. De Ribeiro, Cláudia Barros, Rita Gomes, Catarina Matos, Augusto J. De Reis, Celso A. Rutteman, Gerard R. Gärtner, Fátima
Editor	Seagroves, Tiffany
Copyright Year	2015
Abstract	The tumor microenvironment encompasses several stressful conditions for cancer cells such as hypoxia, oxidative stress and pH alterations. Galectin-3, a well-studied member of the beta-galactoside-binding animal family of lectins has been implicated in multiple steps of metastasis as cell-cell and cell-ECM adhesion, promotion of angiogenesis, cell proliferation and resistance to apoptosis. However, both its aberrantly up- and down-regulated expression was observed in several types of cancer. Thus, the mechanisms that regulate galectin-3 expression in neoplastic settings are not clear. In order to demonstrate the putative role of hypoxia in regulating galectin-3 expression in canine mammary tumors (CMT), in vitro and in vivo studies were performed. In malignant CMT cells, hypoxia was observed to induce expression of galectin-3, a phenomenon that was almost completely prevented by catalase treatment of CMT-U27 cells. Increased galectin-3 expression was confirmed at the mRNA level. Under hypoxic conditions the expression of galectin-3 shifts from a predominant nuclear location to cytoplasmic and membrane expressions. In in vivo studies, galectin-3 was overexpressed in hypoxic areas of primary tumors and well-established metastases. Tumor hypoxia thus up-regulates the expression of galectin-3, which may in turn increase tumor aggressiveness.
Related Links	http://dx.doi.org/10.1371/journal.pone.0134458
Starting Page	134458
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	7
Volume Number	10
Language	English
Publisher	Public Library of Science
Publisher Date	2015-07-29
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Coordinated expression of galectin-3 and galectin-3-binding sites in malignant mammary tumors: implications for tumor metastasis

Extracellular Galectin-3 in Tumor Progression and Metastasis

Sialylation regulates galectin-3/ligand interplay during mammary tumour progression--a case of targeted uncloaking.

Genetic assessment of the importance of galectin-3 in cancer initiation, progression, and dissemination in mice

Cloning of novel mammary tumor progression and metastasis genes

p85β phosphoinositide 3-kinase subunit regulates tumor progression

Regulation of Tumor Progression by Extracellular Galectin-3

Tumor Microenvironment Regulates Metastasis and Metastasis Genes of Mouse MMTV-PymT Mammary Cancer Cells In Vivo

Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors

Hypoxia Up-Regulates Galectin-3 in Mammary Tumor Progression and Metastasis

Similar Documents

Coordinated expression of galectin-3 and galectin-3-binding sites in malignant mammary tumors: implications for tumor metastasis

Extracellular Galectin-3 in Tumor Progression and Metastasis

Sialylation regulates galectin-3/ligand interplay during mammary tumour progression--a case of targeted uncloaking.

Genetic assessment of the importance of galectin-3 in cancer initiation, progression, and dissemination in mice

Cloning of novel mammary tumor progression and metastasis genes

p85β phosphoinositide 3-kinase subunit regulates tumor progression

Regulation of Tumor Progression by Extracellular Galectin-3

Tumor Microenvironment Regulates Metastasis and Metastasis Genes of Mouse MMTV-PymT Mammary Cancer Cells In Vivo

Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors

Hypoxia Up-Regulates Galectin-3 in Mammary Tumor Progression and Metastasis