NDLI: Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice

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Year: 2016, Volume: 7

Year: 2015, Volume: 6

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A gradient of Bmp7 specifies the tonotopic axis in the developing inner ear

In vivo single-molecule imaging identifies altered dynamics of calcium channels in dystrophin-mutant C. elegans

Post-fusion structural changes and their roles in exocytosis and endocytosis of dense-core vesicles

Genome-wide Transcriptome Profiling of Homologous Recombination DNA Repair

Evolutionary triage governs fitness in driver and passenger mutations and suggests targeting never mutations

A genetic and computational approach to structurally classify neuronal types

High throughput detection of miRNAs and gene-specific mRNA at the single-cell level by flow cytometry

NRBF2 Regulates Autophagy and Prevents Liver Injury by Modulating Atg14L-Linked Phosphatidylinositol-3 Kinase III Activity

Temporal spying and concealing process in fibre-optic data transmission systems through polarization bypass

Transposable element islands facilitate adaptation to novel environments in an invasive species

Membrane deformation and scission by the HSV-1 nuclear egress complex

Regulation of the Nav1.5 cytoplasmic domain by Calmodulin

The role of charge-transfer states in energy transfer and dissipation within natural and artificial bacteriochlorophyll-proteins

Generation of organized germ layers from a single mouse embryonic stem cell

Real-time estimation and biofeedback of single-neuron firing rates using local field potentials

Designing quantum dots for solotronics

Contact of cis-Golgi with ER exit sites executes cargo capture and delivery from the ER

Rift migration explains continental margin asymmetry and crustal hyper-extension

Dynamic protein conformations preferentially drive energy transfer along the active chain of the photosystem II reaction centre

A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages

SUMO1 modification stabilizes CDK6 protein and drives the cell cycle and glioblastoma progression

mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synapticlong-term depression in vivo

Hepatoprotective role of Sestrin2 against chronic ER stress

Multi-protein assemblies underlie the mesoscale organization of the plasma membrane

Long-distance endosome trafficking drives fungal effector production during plant infection

Histone H3.3 and its proteolytically processed form drive a cellular senescence program

MORC1 represses transposable elements in the mouse male germline

African origin of the malaria parasite Plasmodium vivax

Spartan deficiency causes genomic instability and progeroid phenotypes

In situ observation of step-edge in-plane growth of graphene in a STEM

Orthogonally modulated molecular transport junctions for resettable electronic logic gates

Combining high-throughput phenotyping and genome-wide association studies to reveal natural genetic variation in rice

Generation of folliculogenic human epithelial stem cells from induced pluripotent stem cells

Assembly of complex plant–fungus networks

HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β

Glycinergic inhibition tunes coincidence detection in the auditory brainstem

Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity

Rag GTPases are cardioprotective by regulating lysosomal function

Nuclear magnetization in gallium arsenide quantum dots at zero magnetic field

Direct evidence for BBSome-associated intraflagellar transport reveals distinct properties of native mammalian cilia

Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism

Microwave spectroscopic observation of distinct electron solid phases in wide quantum wells

A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

Rhythmic oscillations of the microRNA miR-96-5p play a neuroprotective role by indirectly regulating glutathione levels

Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER

Nuclear magnetic resonance spectroscopy with single spin sensitivity

On the fate of pumice rafts formed during the 2012 Havre submarine eruption

Seasonal changes in predator community switch the direction of selection for prey defences

Genomic identification and characterization of the pseudoautosomal region in highlydifferentiated avian sex chromosomes

Combinatorial molecular optimization of cement hydrates

From molecular spectra to a density shift in dense Rydberg gases

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

Adjustment of microbial nitrogen use efficiency to carbon:nitrogen imbalances regulates soil nitrogen cycling

Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles

The cavefish genome reveals candidate genes for eye loss

PICALM modulates autophagy activityand tau accumulation

Noiseless intensity amplification of repetitive signals by coherent addition using the temporal Talbot effect

Protein accumulation in the endoplasmic reticulum as a non-equilibrium phase transition

Identification of renin progenitors in the mouse bone marrow that give rise to B-cell leukaemia

Disrupted auto-regulation of the spliceosomal gene SNRPB causes cerebro–costo–mandibular syndrome

Visualizing domain wall and reverse domain superconductivity

Versatile control of Plasmodium falciparum gene expression with an inducible protein-RNA interaction

Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR

Evolutionary conservation of cold-induced antisense RNAs of FLOWERING LOCUS C in Arabidopsis thaliana perennial relatives

FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability

A source of the single stranded DNA substrate for activation-induced deaminase during somatic hypermutation

Cdo suppresses canonical Wnt signalling via interaction with Lrp6 thereby promoting neuronal differentiation

Arabidopsis cell expansion is controlled by a photothermal switch

Intramuscular adipogenesis is inhibited by myo-endothelial progenitors with functioning Bmpr1a signaling

Self-assembled nanoscale coordination polymers with trigger release properties for effective anticancer therapy

Genetic deficiency of the mitochondrial protein PGAM5 causes a Parkinson’s-like movement disorder

Metastasis is regulated via microRNA-200/ZEB1 axis control of tumor cell PD-L1 expression and intratumoral immunosuppression

Ciliopathy-associated gene Cc2d2a promotes assembly of subdistal appendages on the mother centriole during cilia biogenesis

Male–female communication triggers calcium signatures during fertilization in Arabidopsis

Quantum yield and excitation rate of single molecules close to metallic nanostructures

Structural basis for ion selectivity revealed by high-resolution crystal structure of Mg2+ channel MgtE

Plant cysteine oxidases control the oxygen-dependent branch of the N-end-rule pathway

Facile scission of isonitrile carbon–nitrogen triple bond using a diborane(4) reagent

Competition between items in working memory leads to forgetting

Light and pheromone-sensing neurons regulates cold habituation through insulin signalling in Caenorhabditis elegans

Quantum signatures of a molecular nanomagnet in direct magnetocaloric measurements

Oncogenic Kit signals on endolysosomes and endoplasmic reticulum are essential for neoplastic mast cell proliferation

Erratum: Noiseless intensity amplification of repetitive signals by coherent addition using thetemporal Talbot effect

IKKα negatively regulates ASC-dependent inflammasome activation

Structures of an intramembrane vitamin K epoxide reductase homolog reveal control mechanisms for electron transfer

eIF2B is a decameric guanine nucleotide exchange factor with a γ2ε2 tetrameric core

Magnon transistor for all-magnon data processing

Unexpectedly high pressure for molecular dissociation in liquid hydrogen by electronic simulation

A 3.8-V earth-abundant sodium battery electrode

Exercise training reduces resting heart rate via downregulation of the funny channel HCN4

IL-21 induces IL-22 production in CD4+ T-cells

The contribution of frequency-specific activity to hierarchical information processing in the human auditory cortex

High-mobility transport anisotropy and linear dichroism in few-layer black phosphorus

The Opisthorchis viverrini genome provides insights into life in the bile duct

Submicron structures provide preferential spots for carbon and nitrogen sequestration in soils

Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status

Recurrent ESR1-CCDC170 rearrangements in an aggressive subset of estrogen-receptor positive breast cancers

Retrieving the intracellular topology from multi-scale protein mobility mapping in living cells

Quantification of plasma HIV RNA using chemically-engineered peptide nucleic acids

The DUSP–Ubl domain of USP4 enhances its catalytic efficiency by promoting ubiquitin exchange

Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans

Cooperative secretions facilitate host range expansion in bacteria

Community-integrated omics links dominance of a microbial generalist to fine-tuned resource usage

Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain

Glassiness and exotic entropy scaling induced by quantum fluctuations in a disorder-free frustrated magnet

Kinesin-14 and kinesin-5 antagonistically regulate microtubule nucleation by γ-TuRC in yeast and human cells

Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity

Spider genomes provide insight into composition and evolution of venom and silk

Role of astroglia in Down’s syndrome revealed by patient-derivedhuman-induced pluripotent stem cells

Enrichment of CD56dimKIR+CD57+ highly cytotoxic NK cells in tumor infiltrated lymph nodes of melanoma patients

The evolution of photosynthesis in chromist algae through serial endosymbioses

MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration

Admixture facilitates genetic adaptations to high altitude in Tibet

Chimpanzees modify intentional gestures to coordinate a search for hidden food

Allele-specific genome editing and correction of disease-associated phenotypes in rats using the CRISPR–Cas platform

Structural basis for Smoothened receptor modulation and chemoresistance to anti-cancer drugs

The draft genome of the large yellow croaker reveals well-developed innate immunity

Ligand engaged TCR is triggered by Lck not associated with CD8 coreceptor

Giant dielectric and magnetoelectric responses in insulating nanogranular films at room temperature

Lin28a regulates neuronal differentiation and controls miR-9 production

Identification of a novel salt tolerance gene in wild soybean by whole-genome sequencing

OsAAP6 functions as an important regulator of grain protein content and nutritional quality in rice

Bio-inspired detoxification using 3D-printed hydrogel nanocomposites

FOXO1 Inhibition Yields Functional Insulin-Producing Cells In Human Gut Organoid Cultures

Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributed

Gut microbiome of the Hadza hunter-gatherers

Snail1-dependent control of embryonic stem cell pluripotency and lineage commitment

Processed pseudogenes acquired somatically during cancer development

A fully genetically-encoded protein architecture for optical control of peptide ligand concentration

Evolutionary innovation and conservation in the embryonic derivation of the vertebrate skull

Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T cell differentiation

Population genomics supports baculoviruses as vectors of horizontal transfer of insect transposons

Substrate bound outward-open state of BetP: insights into Na+ coupling

Theory of low-power ultra-broadband terahertz sideband generation in bi-layer graphene

Epigenetic memory of the first cell fate decision prevents complete ES cell reprogramming into trophoblast

Crystal structure of a common GPCR-binding interface for G protein and arrestin

Control of cotton fibre elongation by a homeodomain transcription factor GhHOX3

Antigen capture and archiving by lymphatic endothelial cells following vaccination or viral infection

Separating NADH and NADPH fluorescence in live cells and tissues using FLIM

MHF complex senses branched DNA via binding a pair of crossover DNA duplexes

Glucose-induced electrical activities and insulin secretion in pancreatic islet β-cells are modulated by CFTR

Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction

Engineering light-inducible nuclear localization signals for precise spatiotemporal control of protein dynamics in living cells

STV11 encodes a sulphotransferase and confers durable resistance to rice stripe virus

Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma

Identification of a human neonatal immune-metabolic network associated with bacterial infection

Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talk

Greenhouse conditions induce mineralogical changes and dolomite accumulation in coralline algae on tropical reefs

Switchable imbibition in nanoporous gold

Unc5C and DCC act downstream of Ctip2 and Satb2 and contribute to corpus callosum formation

STIM1 triggers a gating rearrangement at the extracellular mouth of the ORAI1 channel

Modest CaV1.342-selective inhibition by compound 8 is β-subunit dependent

Experimental orthotopic transplantation of a tissue-engineered oesophagus in rats

AmiA is a penicillin target enzyme with dual activity in the intracellular pathogen Chlamydia pneumoniae

Proton-coupled sugar transport in the prototypical major facilitator superfamily protein XylE

Cardiac arrhythmia induced by genetic silencing of“funny” (f) channels is rescued by GIRK4inactivation

Global link between deformation and volcanic eruption quantified by satellite imagery

Ultralow mode-volume photonic crystal nanobeam cavities for high-efficiency coupling to individual carbon nanotube emitters

Ambidextrous Binding of Cell and Membrane Bilayers by Soluble Matrix Metalloproteinase-12

The correlation between reading and mathematics ability at age twelve has a substantial genetic component

Evolutionarily Conserved Coupling of Adaptive and Excitable Networks Mediates Eukaryotic Chemotaxis

Unravelling the multilayer growth of the fullereneC60 in real time

Maspin is not required for embryonic development or tumour suppression

Poisson’s ratio of individual metal nanowires

Discovery of gigantic molecular nanostructures using a flow reaction array as a searchengine

Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosismurine model

A magnetic compass aids monarch butterfly migration

Pigment cell interactions and differential xanthophore recruitment underlying zebrafish stripe reiteration and Danio pattern evolution

Comparative genome sequencing reveals genomic signature of extreme desiccation tolerance in the anhydrobiotic midge

Microhomology-mediated end-joining-dependent integration of donor DNA in cells and animals using TALENs and CRISPR/Cas9

Disruption of astrocyte-vascular coupling and the blood-brain barrier by invading glioma cells

Duplication of a promiscuous transcription factor drives the emergence of a new regulatory network

Protruding knob-like proteins violate local symmetries in an icosahedral marine virus

High-quality genome (re)assembly using chromosomal contact data

Intensification of the meridional temperature gradient in the Great Barrier Reef following the Last Glacial Maximum

Mutually beneficial host exploitation and ultra-biased sex ratios in quasisocial parasitoids

A highly abundant bacteriophage discovered in the unknown sequences of human faecalmetagenomes

Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients

Observation of strongly entangled photon pairs from a nanowire quantum dot

EphrinB2 Affects Apical Constriction in Xenopus Embryos and is Regulated by ADAM10 and Flotillin-1

A critical analysis of calcium carbonate mesocrystals

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

SKN-1 and Nrf2 couples proline catabolism with lipid metabolism during nutrient deprivation

The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein

Free-surface molecular command systems for photoalignment of liquid crystalline materials

GWAS identifies four novel eosinophilic esophagitis loci

Integrating artificial with natural cells to translate chemical messages that direct E. coli behaviour

A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation

Hypothalamic inhibition of socio-sexual behaviour by increasing neuroestrogen synthesis

Role for MMP-9 in stress-induced downregulation of nectin-3 in hippocampal CA1 and associated behavioural alterations

Structural analyses of Ca2+/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation

Topological transport and atomic tunnelling–clustering dynamics for aged Cu-doped Bi2Te3 crystals

Retinoic acid signalling regulates the development of tonotopically patterned hair cells in the chicken cochlea

Mobile elements drive recombination hotspots in the core genome of Staphylococcus aureus

Genome flux and stasis in a five millennium transect of European prehistory

Molecular basis for erythromycin-dependent ribosome-stalling during translation of the ErmBL leader peptide

TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease

Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA

Glucocerebrosidase regulates perpetual cell-to-cell transmission of α-synuclein

Protein co-translocational unfolding depends on the direction of pulling

Diurnal suppression of EGFR signalling by glucocorticoids and implications for tumour progression and treatment

The Staphylococcal Toxins γ-Hemolysin AB and CB Differentially Target Phagocytes by Employing Specific Chemokine Receptors

Probing the solar corona with very long baseline interferometry

Gαs regulates the post-endocytic sorting of G protein-coupled receptors

A liquid crystalline chirality balance for vapours

MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL

4′-O-substitutions determine selectivity of aminoglycoside antibiotics

Genetic characterization of Greek population isolates reveals strong genetic drift at missense and trait-associated variants

Simultaneous downregulation of KLF5 and Fli1 is a key feature underlying systemic sclerosis

Pathological α-synucleinimpairs adult-born granule cell development and functional integration in the olfactorybulb

Dynamics of a producer-freeloader ecosystem on the brink of collapse

Highly mesoporous metal–organic framework assembled in a switchable solvent

The refractive index and electronic gap of water and ice increase with increasing pressure

Shh-mediated degradation of Hhip allows cell autonomous and non-cell autonomous Shh signaling

Rotated waveplates in integrated waveguide optics

The tumour suppressor DLC2 ensures mitotic fidelity by coordinating spindle positioning and cell–cell adhesion

Receptor interacting protein 140 attenuates endoplasmic reticulum stress in neurons and protects against cell death

Size-independent symmetric division in extraordinarily long cells

Bio-optimized energy transfer in densely packed fluorescent protein enables near-maximal luminescence and solid-state lasers

Pressure–temperature evolution of primordial solar system solids during impact-induced compaction

Whisker barrel cortex delta oscillations and gamma power in the awake mouse are linked to respiration

An alternate binding site for PPARγ ligands

Room temperature high-fidelity holonomic single-qubit gate on a solid-state spin

Streptomycin potency is dependent on MscL channel expression

Hydrodynamic alignment and assembly of nanofibrils resulting in strong cellulose filaments

Single-molecule diffusion and conformational dynamics by spatial integration of temporal fluctuations

Impact of residues remote from the catalytic centre on enzyme catalysis of copper nitrite reductase

Transcriptome Meta-Analysis of Lung Cancer Reveals Recurrent Aberrations in NRG1 and Hippo Pathway Genes

Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart

The X-ray crystal structure of the euryarchaeal RNA polymerase in an open clamp configuration

Active control of magnetoresistance of organic spin valves using ferroelectricity

Transmission from the dominant input shapes the stereotypic ratio of photoreceptor inputs onto horizontal cells

Iridium Oxide Nanotube Electrodes for Highly Sensitive and Prolonged Intracellular Measurement of Action Potentials

XTACC3–XMAP215 association reveals an asymmetric interaction promoting microtubule elongation

Compact genome of the Antarctic midge is likely an adaptation to an extreme environment

Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers

Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole

Activation of diverse signaling pathways by oncogenic PIK3CA mutations

Site occupancy of interstitial deuterium atoms in face-centred cubic iron

Amyloid-Associated Activity Contributes to the Severity and Toxicity of a Prion Phenotype

Epigenetic silencing of miR-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infection

Siple Dome ice reveals two modes of millennial CO2 change during the last ice age

Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia

Cdk5-mediated phosphorylation of RapGEF2 controls neuronal migration in the developing cerebral cortex

DNA-based digital tension probes reveal integrin forces during early celladhesion

A general strategy for developing cell-permeable photo-modulatable organic fluorescent probes for live-cell super-resolution imaging

Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice

Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle

A paracrine network regulates the cross-talk between human lung stem cells and the stroma

A Snail1/Notch1 Signaling Axis Controls Embryonic Vascular Development

Unencapsulated Streptococcus pneumoniae from conjunctivitis encode variant traits and belong to a distinct phylogenetic cluster

Drawing a high-resolution functional map of adeno-associated virus capsid by massively parallel sequencing

Characterizing inner-shell with spectral phase interferometry for direct electric-field reconstruction

Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate

O-GlcNAc-mediated interaction between VER2 and TaGRP2 elicits TaVRN1 mRNA accumulation during vernalization in winter wheat

EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia

A tetrahelical DNA fold adopted by tandem repeats of alternating GGG and GCG tracts

Chemical–genetic attenuation of focal neocortical seizures

Reconstituting ring-rafts in bud-mimicking topography of model membranes

Overproduction of stomatal lineage cells in Arabidopsis mutants defective in active DNA demethylation

CIRCADIAN RHYTHM REPROGRAMMING DURING LUNG INFLAMMATION

Frequency domain optical parametric amplification

The role of maternal-specific H3K9me3 modification in establishing imprinted X-chromosome inactivation and embryogenesis in mice

Live-cell multiplane three-dimensional super-resolution optical fluctuation imaging

Cellular Protection using Flt3 and PI3Kα inhibitors demonstrates multiple mechanisms of oxidative glutamate toxicity

Long-range ordered vorticity patterns in living tissue induced by cell division

Few-layer molybdenum disulfide transistors and circuits for high-speed flexible electronics

Untethered micro-robotic coding of three-dimensional material composition

Structural basis for catalysis in a CDP-alcohol phosphotransferase

Membrane curvature sensing by the C-terminal domain of complexin

Skp2 suppresses apoptosis in Rb1 deficient tumors by limiting E2F1 activity

Plant genomes enclose footprints of past infections by giant virus relatives

Physiological and genomic features of highly alkaliphilic hydrogen-utilizing Betaproteobacteria from a continental serpentinizing site

Molecular basis for bacterial peptidoglycan recognition by LysM domains

Cytoplasmic Dynein Transports Cargos via Load-Sharing between the Heads

Lactate racemase is a nickel-dependent enzyme activated by a widespread maturation system

TENSION ON THE LINKER GATES THE ATP-DEPENDENT RELEASE OF DYNEIN FROM MICROTUBULES

Structural basis for biomolecular recognition in overlapping binding sites in a diiron enzyme system

Cell wall precursors are required to organize the chlamydial division septum

The Spirodela polyrhiza genome reveals insights into its neotenous reduction fast growth and aquatic lifestyle

Superficial layer pyramidal cells communicate heterogeneously between multiple functional domains of cat primary visual cortex

Ecological succession of a Jurassic shallow-water ichthyosaur fall

Photon-assisted tunnelling with nonclassical light

A Cenozoic-style scenario for the end-Ordovician glaciation

Kainate receptor activation induces glycine receptor endocytosis through PKC deSUMOylation

Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach

Optical control of insulin release using a photoswitchable sulfonylurea

Radial Symmetry in a Chimaeric Glutamate Receptor Pore

Identification of genetic variants associated with alternative splicing using sQTLseekeR

Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails

Tcf3 promotes cell migration and wound repair through regulation of lipocalin 2

An ecdysone-responsive nuclear receptor regulates circadian rhythms in Drosophila

A glutamatergic reward input from the dorsal raphe to ventral tegmental area dopamine neurons

A Meta-Analysis of Hodgkin Lymphoma Reveals 19p13.3 TCF3 as a Novel Susceptibility Locus

An atomic model of brome mosaic virus using direct electron detection and real-space optimization

An electromagnetic field disrupts negative geotaxis in Drosophila via a CRY-dependent pathway

Multiple recent horizontal transfers of a large genomic region in cheese making fungi

Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut

Complex self-assembly of pyrimido[4,5-d]pyrimidine nucleoside supramolecular structures

A nairovirus isolated from African bats causes haemorrhagic gastroenteritis and severe hepatic disease in mice

Adaptive introgression between Anopheles sibling species eliminates a major genomicisland but not reproductive isolation

Guided and magnetic self-assembly of tunable magnetoceptive gels

Swimming by reciprocal motion at low Reynolds number

Missing driver in the Sun–Earth connection from energetic electron precipitation impacts mesospheric ozone

Controlled multistep synthesis in a three-phase droplet reactor

Temporal disease trajectories condensed from population-wide registry data covering 6.2 million patients

Clathrin light chains are required for the gyrating-clathrin recycling pathway and thereby promote cell migration

Observation of a quantum Cheshire Cat in a matter-wave interferometer experiment

Fairness violations elicit greater punishment on behalf of another than for oneself

Regulation of human telomerase splicing by RNA:RNA pairing

SiO and CH3OH mega-masers in NGC 1068

The Glanville fritillary genome retains an ancient karyotype and reveals selective chromosomal fusions in Lepidoptera

DOCK8 regulates protective immunity by controlling the function and survival of RORγt+ ILCs

Mapping the spatial distribution of charge carriers in quantum-confined heterostructures

The fidelity of the ligation step determines how ends are resolved during Nonhomologous end joining

LSD1 promotes oxidative metabolism of white adipose tissue

Photo-enhanced antinodal conductivity in the pseudogap state of high-T c cuprates

Receptor mimicry by antibody F045-092 facilitates universal binding to the H3 subtype of influenza virus

Lamb-Dicke spectroscopy of atoms in a hollow-core photonic crystal fibre

Morphological and functional remodeling of the neuromuscular junction by skeletal muscle PGC-1α

Species-specific defence responses facilitate conspecifics and inhibit heterospecifics in above–belowground herbivore interactions

Epigenetic regulation of Atrophin1 by lysine-specific demethylase 1 is required for cortical progenitor maintenance

Fc gamma receptor-TLR cross-talk elicits pro-inflammatory cytokine production by human M2 macrophages

Magnetization amplified by structural disorder within nanometre-scale interface region

Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans

Size and frequency of natural forest disturbances and the Amazon forest carbon balance

Super-resolution imaging and tracking of protein–protein interactions in sub-diffraction cellular space

Functionally diverse dendritic mRNAs rapidly associate with ribosomes following a novel experience

Critical roles of nardilysin in the maintenance of body temperature homoeostasis

A scaling law for random walks on networks

RNA-binding proteins regulate the expression of the immune activating ligand MICB

Senescence impairs direct conversion of human somatic cells to neurons

Fabrication of enzyme-degradable and size-controlled protein nanowires using single particle nano-fabrication technique

Phosphoregulation of Ire1 RNasesplicing activity

ARGONAUTE PIWI domain and microRNA duplex structure regulate small RNA sorting in Arabidopsis

Global profiling of co- and post-translationally N-myristoylated proteomes in human cells

The full-length cell–cell fusogen EFF-1 is monomeric and upright on the membrane

Middle-Eastern plant communities tolerate 9 years of drought in a multi-site climate manipulation experiment

Frequent mutations in chromatin-remodeling genes in pulmonary carcinoids

Functional Analysis of a De Novo GRIN2A Missense Mutation Associated with Early-onset Epileptic Encephalopathy

Restoration of the third law in spin ice thin films

An ultralow power athermal silicon modulator

Lactate-mediated glia-neuronal signalling in the mammalian brain

Interlocked DNA nanostructures controlled by a reversible logic circuit

Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen

Universal dispersion of surface plasmons in flat nanostructures

Ancestral repeats have shaped epigenome and genome composition for millions of years in Arabidopsis thaliana

Bacteria slingshot more on soft surfaces

Structural reorganization of cylindrical nanoparticles triggered by polylactide stereocomplexation

Distinct structural features of TFAM drive mitochondrial DNA packaging versus transcriptional activation

Systemic regulatory mechanisms of mammalian aging and longevity bybrain sirtuins

A global non-coding RNA system modulates fission yeast protein levels in response tostress

Temporally selective contextual encoding in the dentate gyrus of the hippocampus

Postmortem examination of patient H.M.’s brain based on histological sectioning and digital 3D reconstruction

The landscape of kinase fusions in cancer

Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle

A random six-phase switch regulates pneumococcal virulence via global epigenetic changes

Mutations in Alström Protein Impair Terminal Differentiation of Cardiomyocytes

The actin homologue MreB organizes the bacterial cell membrane

Extreme diving behaviour in devil rays links surface waters and the deep ocean

Increased Notch signaling inhibits anoikis and stimulates proliferation of prostate luminal epithelial cells

Structural analysis of the transitional state of Arp2/3 complex activation by two actin-WCAs

Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy

Dynamic Localization of Electronic Excitation in Photosynthetic Complexes Revealed with Chiral Two-Dimensional Spectroscopy

The oil palm VIRESCENS gene controls fruit colour and encodes a R2R3-MYB

Spin Hall voltages from a.c. and d.c. spin currents

Gene co-expression network analysis reveals common system-level properties of prognostic genes across cancer types

Clusterin facilitates stress-induced lipidation of LC3 and autophagosome biogenesis to enhance cancer cell survival

A role for sorting nexin 27 in AMPA receptor trafficking

Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease

Virtual finger boosts three-dimensional imaging and microsurgery as well as terabyte volume image visualization and analysis

Field-induced assembly of colloidal ellipsoids into well-defined microtubules

Positron emission tomography and functional characterization of a complete PBR/TSPO knockout

High-Throughput and Combinatorial Gene Expression on a Chip for Metabolism-Induced Toxicology Screening

Contrasting benefits of different artemisinin combination therapies as first-line malaria treatments using model-based cost-effectiveness analysis

Modulator-free quadrature amplitude modulation signal synthesis

Structure and function of a spectrin-like regulator of bacterial cytokinesis

Trapping of drops by wetting defects

Tipping elements in the human intestinal ecosystem

IRF8 suppresses pathological cardiac remodelling by inhibiting calcineurin signalling

Observation of soliton compression in silicon photonic crystals

Turning a band insulator into an exotic superconductor

Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis

Extrachromosomal driver mutations in glioblastoma and low grade glioma

Double-sieving-defective aminoacyl-tRNA synthetase causes protein mistranslation and affects cellular physiology and development

Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer

Real-time earthquake monitoring using a search engine method

Defect-induced supersolidity with soft-core bosons

Diversification of bacterial genome content through distinct mechanisms over different timescales

The complex jujube genome provides insights into fruit tree biology

Mitotic catenation is monitored and resolved by a PKCε-regulated pathway

Regulated spatial organization and sensitivity of cytosolic protein oxidation in Caenorhabditis elegans

The Brassica oleracea genome reveals the asymmetrical evolution of polyploidgenomes

Graphene-based carbon-layered electrode array technology for neural imaging and optogenetic applications

A gatekeeper helix determines the substrate specificity of Sjögren–Larsson Syndrome enzyme fatty aldehyde dehydrogenase

Threading plasmonic nanoparticle strings with light

The MK2/3 cascade regulates AMPAR trafficking and cognitive flexibility

Structural basis for microtubule recognition by the human kinetochore Ska complex

The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation

Quantitative super-resolution imaging of Bruchpilot distinguishes active zone states

Agronomic conditions and crop evolution in ancient Near East agriculture

Elastic anisotropy of experimental analogues of perovskite and post-perovskite help to interpret D′′ diversity

Three functionally distinct classes of C-fiber nociceptors in primate

Distinct aspects of frontal lobe structure mediate age-related differences in fluid intelligence and multitasking

Chemical control of electrical contact to sp 2 carbon atoms

Uncovering many-body correlations in nanoscale nuclear spin baths by central spindecoherence

A toggle-switch controls the low pH-triggered rearrangement and maturation of the dengue virus envelope proteins

Interplay between phosphorylation and SUMOylation events determines CESTA protein fate in brassinosteroid signaling

Lateral opening of the bacterial translocon on ribosome binding and signal peptide insertion

A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice

A critical base pair in k-turns that confers folding characteristics and correlates with biological function

Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders

In-line alignment and Mg2+ coordination at the cleavage site of the env22 twister ribozyme

‘Division of labour’ in response to host oxidative burst drives a fatal Cryptococcus gattii outbreak

Rapid control of phase growth by nanoparticles

Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumour

A highly efficient cocaine detoxifying enzyme obtained by computational design

Dynamic Phosphorylation of HP1α Regulates Mitotic Progression in Human Cells

Invertebrate extracellular phagocyte traps show that chromatin is an ancient defence weapon

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7

A genome-wide map of hyper-edited RNA reveals numerous new sites

Conserved and host-specific features of influenza virion architecture

An assay to image neuronal microtubule dynamics in mice

FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation

Polymersome magneto-valves for reversible capture and release of nanoparticles

The origin of the bifurcated axial skeletal system in the twin-tail goldfish

Enantioselective recognition at mesoporous chiral metal surfaces

CpG island-mediated global gene regulatory modes in mouse embryonic stem cells

Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain

Magneto-Fluorescent Core-Shell Supernanoparticles

A plant factory for moth pheromone production

A chemo-centric view of human health and disease

Engineering thermal conductance using a two-dimensional phononic crystal

X-ray refinement significantly underestimates the level of microscopic heterogeneity in biomolecular crystals

Experimental demonstration of spinor slow light

Cotton cytochrome P450 CYP82D regulates systemic cell death by modulating the octadecanoid pathway

Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

Hydrochromic conjugated polymers for human sweat pore mapping

Evidence for global cooling in the Late Cretaceous

Substrate–water exchange in photosystem II is arrested before dioxygen formation

Enhanced role of eddies in the Arctic marine biological pump

Centrin3 in trypanosomes maintains the stability of a flagellar inner-arm dynein for cell motility

Arteries are formed by vein-derived endothelial tip cells

Common variation near ROBO2 is associated with expressive vocabulary in infancy

The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling

HGK/MAP4K4 deficiency induces TRAF2 stabilization and Th17 differentiation leading to insulin resistance

Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk

p85α recruitment by the CD300f phosphatidylserine receptor mediates apoptotic cell clearance required for autoimmunity suppression

Strong antenna-enhanced fluorescence of a single light-harvesting complex shows photon antibunching

Neuronal adaptation involves rapid expansion of the action potential initiation site

Development of pro-apoptotic peptides as potential therapy for peritoneal endometriosis

Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression

A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains

Pharmacological Targeting of the Mammalian Clock Regulates Sleep Architecture and Emotional Behavior

CSN6 drives carcinogenesis by positively regulating Myc stability

A cochlear-bone wave can yield a hearing sensation as well as otoacoustic emission

Caste-specific RNA editomes in the leaf-cutting ant Acromyrmex echinatior

Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1

Switching plastic crystals of colloidal rods with electric fields

Energy-filtered cold electron transport at room temperature

The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin

Motor contributions to the temporal precision of auditory attention

Electroformation of Janus and patchy capsules

Superabsorption of light via quantum engineering

Rapid detection of single bacteria in unprocessed blood using Integrated Comprehensive Droplet Digital Detection

Integration of molecular and enzymatic catalysts on graphene for biomimetic generation of antithrombotic species

Anisotropic energy flow and allosteric ligand binding in albumin

Evidence for external forcing of the Atlantic Multidecadal Oscillation since termination of the Little Ice Age

RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells

Treatment of acute lung injury by targeting MG53-mediated cell membrane repair

Multiple enzymatic activities of ParB/Srx superfamily mediate sexual conflict among conjugative plasmids

Integrated Analysis of Germline and Somatic Variants in Ovarian Cancer

Carbon Nanotubes as in vivo Bacterial Probes

Microfluidic Probe for Single-Cell Lysis and Analysis in Adherent Tissue Culture

Geographic population structure analysis of worldwide human populations infers their biogeographical origins

Ion antiport accelerates photosynthetic acclimation in fluctuating light environments

Decelerated genome evolution in modern vertebrates revealed by analysis of multiple lancelet genomes

High-temperature antiferromagnetism in molecular semiconductor thin films and nanostructures

A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans

Audience preferences are predicted by temporal reliability of neural processing

Histamine H3 receptors aggravate cerebral ischaemic injury by histamine-independent mechanisms

Estimates of the changing age-burden of Plasmodium falciparum malaria disease in sub-Saharan Africa

Rydberg atoms in hollow-core photonic crystal fibres

Implementation of the CRISPR-Cas9 system in fission yeast

TNF-α blockade induces IL-10 expression in human CD4+ T cells

STAT3 restrains RANK- and TLR4-mediated signaling by suppressing expression of the E2 ubiquitin ligase Ubc13

Lysosome sorting of β-glucocerebrosidase by LIMP-2 is targeted by the mannose 6-phosphate receptor

An engineered pathway for the biosynthesis of renewable propane

Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation

Structural and functional conservation of fungal MatA and human SRY sex determining proteins

Activity-dependent facilitation of Synaptojanin and synaptic vesicle recycling by the Minibrain kinase

Thermoelectric Seebeck effect in oxide-based resistive switching memory

G1-arrested newborn cells are the predominant infectious form of the pathogen Brucella abortus

Warped linear mixed models for the genetic analysis of transformed phenotypes

Aggregation and morphology control enables multiple cases of high-efficiency polymer solar cells

The immune synapse clears and excludes molecules above a size threshold

Presynaptic GABAergic inhibition regulated by BDNF contributes to neuropathic pain induction

Chlamydia infection depends on a functional MDM2-p53 axis

MHC-dependent inhibition of uterine NK cells impedes fetal growth and decidual vascular remodelling

Kinase fusions are frequent in Spitz tumors and spitzoid melanomas

Genome-wide association study of Arabidopsis thaliana's leaf microbial community

KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two steps

Direct recognition of homology between double helices of DNA in Neurospora crassa

Visualizing active membrane protein complexes by electron cryotomography

A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a

Chd5 orchestrates chromatin remodeling during sperm development

Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells

Metabolome-based genome-wide association study of maize kernel leads to novel biochemical insights

Nitrogen stress response and stringent response are coupled in Escherichia coli

Cell death versus cell survival instructed by supramolecular cohesion of nanostructures

Using geospatial modeling to optimize the rollout of antiretroviral-based pre-exposure HIV interventions in Sub-Saharan Africa

Pathological roles of the VEGF/SphK pathway in Niemann–Pick type C neurons

Neuroplasticity-based computerized cognitive remediation for treatment resistant geriatric depression

Grain rotation mediated by grain boundary dislocations in nanocrystalline platinum

Bright and fast multi-colored voltage reporters via electrochromic FRET

MicroRNA-378 controls classical brown fat expansion to counteract obesity

The switching role of β-adrenergic receptor signalling in cell survival or death decision of cardiomyocytes

p38 MAPK-inhibited dendritic cells induce superior antitumor immune responses and overcome regulatory T cell-mediated immunosuppression

The structure and substrate specificity of human Cdk12/Cyclin K

Corrigendum: R-loops and nicks initiate DNA breakage and genome instability in non-growing Escherichia coli

A Smart and Versatile Theranostic Nanomedicine Platform based on Nanoporphyrin

ERG induces taxane resistance in castration-resistant prostate cancer

Understanding functional miRNA–target interactions in vivo by site-specific genome engineering

Action-value comparisons in the dorsolateral prefrontal cortex control choice between goal-directed actions

Actin–microtubule coordination at growing microtubule ends

Deficient Wnt signalling triggers striatal synaptic degeneration and impaired motor behaviour in adult mice

MicroRNA-302b augments host defense to bacteria by regulating inflammatory responses via feedback to TLR/IRAK4 circuits

Heterogeneity of genomic evolution and mutational profiles in multiple myeloma

Transcriptional specialization of human dendritic cell subsets in response to microbial vaccines

The dynamic surface tension of atmospheric aerosol surfactants reveals new aspects of cloud activation

Large arteriolar component of oxygen delivery implies safe margin of oxygensupply to cerebral tissue

Ferroelectric translational antiphase boundaries in nonpolar materials

The European functional tree of bird life in the face of global change

Haemodynamic and extracellular matrix cues regulate the mechanical phenotype and stiffness of aortic endothelial cells

Sub-15-nm patterning of asymmetric metal electrodes and devices by adhesion lithography

Extracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approach

Chromatin retention of DNA damage sensors DDB2 and XPC through loss of p97 segregase causes genotoxicity

Halogen-bonded mesogens direct polymer self-assemblies up to millimetre length scale

High mobility explains demand sharing and enforced cooperation in egalitarian hunter-gatherers

Cavity-free plasmonic nanolasing enabled by dispersionless stopped light

The single-channel regime of transport through random media

Ancient homology underlies adaptive mimetic diversity across butterflies

Unique Features of the m6A Methylome in Arabidopsis thaliana

The structural basis for receptor recognition of human interleukin-18

Corrigendum: Bats host major mammalian paramyxoviruses

Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signaling

A micro-sterile inflammation array as an adjuvant for influenza vaccines

Ultra-responsive soft matter from strain-stiffening hydrogels

2’f-OMe-phosphorodithioate modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity

Variation in Arabidopsis flowering time associated with cis-regulatory variation in CONSTANS

Strong effects of genetic and lifestyle factors on biomarker variation and use of personalized cutoffs

Vanillin formation from ferulic acid in Vanilla planifolia is catalysed by a single enzyme

TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends

The rainbow trout genome provides novel insights into evolution after whole-genome duplication in vertebrates

Cell Division and Targeted Cell Cycle Arrest Opens and Stabilizes Basement Membrane Gaps

The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer

A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites

A two-locus interaction causes interspecific hybrid weakness in rice

Klebsormidium flaccidum genome reveals primary factors for plant terrestrialadaptation

Local mapping of detector response for reliable quantum state estimation

Petawatt laser absorption bounded

Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival

Theoretical predictions for hot-carrier generation from surface plasmon decay

Vascular channels formed by subpopulations of PECAM1+ melanoma cells

HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells

Platinum-modified covalent triazine frameworks hybridized with carbon nanoparticles as methanol-tolerant oxygen reduction electrocatalysts

Ordered three-dimensional interconnected nanoarchitectures in anodic porous alumina

Spectral interferometric microscopy reveals absorption by individual optical nanoantennas from extinction phase

One order of magnitude faster phase change at reduced power in Ti-Sb-Te

IP6K Structure and the Molecular Determinants of Catalytic Specificity in an Inositol Phosphate Kinase Family

Alternative meiotic chromatid segregation in the holocentric plant Luzula elegans

Dehydration and crystallization of amorphous calcium carbonate in solution and in air

Organic semiconductor density of states controls the energy level alignment at electrode interfaces

TRPA1 is essential for the vascular response to environmental cold exposure

Glassy states and super-relaxation in populations of coupled phase oscillators

Conformational targeting of intracellular Aβ oligomers demonstrates their pathological oligomerization inside the endoplasmic reticulum

Evading the strength–ductility trade-off dilemma in steel through gradient hierarchical nanotwins

CD95 and CD95L promote and protect cancer stem cells

The meta-epigenomic structure of purified human stem cell populations is defined at cis-regulatory sequences

Suppressing subordinate reproduction provides benefits to dominants in cooperative societies of meerkats

Holocene variations in peatland methane cycling associated with the Asian summer monsoon system

Global warming favours light-coloured insects in Europe

miR-191 and miR-135 are required for long-lasting spine remodeling associated with synaptic long term depression

Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity

Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy

Identification of the remains of King Richard III

Nasal immunity is an ancient arm of the mucosal immune system of vertebrates

A synthetic sex ratio distortion system for the control of the human malaria mosquito

Superconducting graphene sheets in CaC6 enabled by phonon-mediated interband interactions

Constitutive phospholipid scramblase activity of a G Protein-coupled receptor*

Transcriptional control of ROS homeostasis by KUODA1 regulates cell expansion during leaf development

Pathogenic potential of interferon αβ in acute influenza infection

Long non-coding RNA-mediated transcriptional interference of a permease gene confers drug tolerance in fission yeast

Structural insight into SUMO chain recognition and manipulation by the ubiquitin ligase RNF4

Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway

Predicting the risk of avian influenza A H7N9 infection in live-poultry markets across Asia

GATA-dependent regulatory switches establish atrioventricular canal specificity during heart development

Second-harmonic generation using -quasi-phasematching in a GaAs whispering-gallery-mode microcavity

Conformational Transitions and Stop-and-Go Nanopore Transport of Single Stranded DNA on Charged Graphene

Twinning-like lattice reorientation without a crystallographic twinning plane

DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts

Activated astrocytes enhance the dopaminergic differentiation of stem cells and promote brain repair through bFGF

Targeting β-catenin signaling for therapeutic intervention in MEN1-deficient pancreatic neuroendocrine tumours

Quantum metrology with parametric amplifier-based photon correlation interferometers

An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration

Injectable Bioadhesive Hydrogels with Innate Antibacterial Properties

Coccolithophore calcification response to past ocean acidification and climate change

Ubiquitin-Binding Site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23

A pan-cancer proteomic perspective on The Cancer Genome Atlas

PKM2 phosphorylates MLC2 and regulates cytokinesis of tumor cells

High-Resolution Structure and Mechanism of an F/V-Hybrid Rotor Ring in a Na+-coupled ATP Synthase

Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication

Rapid in vivo detection of isoniazid-sensitive Mycobacterium tuberculosis by breath test

The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A

SILAC-based proteomic quantification of chemoattractant-induced cytoskeleton dynamics on a second to minute timescale

Sonic hedgehog-expressing cells in the developing limb measure time by an intrinsic cell cycle clock

Cell type-specific delivery of short interfering RNAs by dye-functionalised theranostic nanoparticles

THE ORIGIN OF SEGMENTATION MOTOR ACTIVITY IN THE INTESTINE

An intestinal commensal symbiosis factor controls neuroinflammation via TLR2-mediated CD39 signaling

Control of membrane gaps by synaptotagmin-Ca2+ measured with a novel membrane distance ruler

Potential climate engineering effectiveness and side effects during a high carbon dioxide-emission scenario

Divergent Paths for the Selection of Immunodominant Epitopes from Distinct Antigenic Sources

Dynamic strain-mediated coupling of a single diamond spin to a mechanical resonator

A hybrid absorption–adsorption method to efficiently capture carbon

Corrigendum: Whole-genome sequencing of bladder cancers reveals somatic CDKN1Amutations and clinicopathological associations with mutation burden

A molecular brake controls the magnitude of long-term potentiation

Activation of RidA chaperone function by N-chlorination

Early warning signals of Atlantic Meridional Overturning Circulation collapse in a fully coupled climate model

Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation

Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline

A unified design space of synthetic stripe-forming networks

Ligand substitutions between ruthenium–cymene compounds can control protein versus DNA targeting and anticancer activity

Independent recruitment of Igh alleles in V(D)J recombination

Timescales for detecting a significant acceleration in sea level rise

Rewiring neural circuits by the insertion of ectopic electrical synapses in transgenic C. elegans

Imaging live cell in micro-liquid enclosure by X-ray laser diffraction

Vibrio cholerae use pili and flagella synergistically to effect motility switching and conditional surface attachment

In vivo imaging of specific drug target binding at subcellular resolution

Acquisition of innate-like microbial reactivity in mucosal tissues during human fetal MAIT-cell development

MitoNEET-Mediated Effects on Browning of White Adipose Tissue

Germination and infectivity of microconidia in the rice blast fungus Magnaportheoryzae

The impact of the metabotropic glutamate receptor and other gene family interactionnetworks on autism

Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection

Hypoxia-Inducible Hydrogels

Made-to-order metal-organic frameworks for trace carbon dioxide removal and air capture

Cascading ecological effects of eliminating fishery discards

Partial melting of deeply subducted eclogite from the Sulu orogen in China

Self-assembly and modular functionalization of three-dimensional crystals from oppositely charged proteins

Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A

Erratum: High genome heterozygosity and endemic genetic recombination in the wheat stripe rust fungus

Differential Developmental Requirement and Peripheral Regulation for Dermal Vγ4 and Vγ6T17 Cells in Health and Inflammation

Environment-responsive Nanophores for Therapy and Treatment Monitoring via Molecular MRI Quenching

A cortical-spinal prosthesis for targeted limb movement in paralyzed primate avatars

Character displacement of Cercopithecini primate visual signals

Three-dimensional imaging of cavity vacuum with single atoms localized by a nanohole array

A red-shifted fluorescent substrate for aldehyde dehydrogenase

Opening up communications

Mechanistic determinants of the directionality and energetics of active export by aheterodimeric ABC transporter

Regulating proton-coupled electron transfer for efficient water splitting by manganese oxides at neutral pH

Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site

Translocation between PI(4,5)P2-poor and PI(4,5)P2-rich microdomains during store depletion determines STIM1 conformation and Orai1 gating

Recurrent de novo mutations implicate novel genes underlying simplex autism risk

A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect

Familial Alzheimer’s mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site

Sex pheromone biosynthetic pathways are conserved between moths and the butterfly Bicyclus anynana

Inertio-elastic focusing of bioparticles in microchannels at high throughput

Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo

TRPV2 is critical for the maintenance of cardiac structure and function in mice

Self-propagating high-temperature synthesis for compound thermoelectrics and new criterion for combustion processing

DNA methylation signatures link prenatal famine exposure to growth and metabolism

Liquid crystal-enabled electro-osmosis through spatial charge separation in distorted regions as a novel mechanism of electrokinetics

Functionally reciprocal mutations of the prolactin signalling pathway define hairy and slick cattle

Endogenous florendoviruses are major components of plant genomes and hallmarks of virus evolution

A 3D insight on the catalytic nanostructuration of few-layer graphene

Highly modular bow-tie gene circuits with programmable dynamic behavior

Forests fuel fish growth in freshwater deltas

Dynamic heterogeneity controls diffusion and viscosity near biological interfaces

A prominent and conserved role for YY1 in Xist transcriptional activation

Lattice-free prediction of three-dimensional structure of programmed DNA assemblies

Satellite telemetry and social modeling offer new insights into the origin of primate multilevel societies

Afforestation or intense pasturing improve the ecological and economic value of abandoned tropical farmlands

Target control of complex networks

Optical properties of relativistic plasma mirrors

2q36.3 is associated with prognosis for oestrogenreceptor-negative breast cancer patients treated withchemotherapy

Targeted genomic rearrangements using CRISPR/Cas technology

Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X

All-optical phase modulation in a cavity-polariton Mach–Zehnder interferometer

SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age

Consequences of tropical land use for multitrophic biodiversity and ecosystem functioning

Visualized effect of oxidation on magnetic recording fidelity in pseudo-single-domain magnetite particles

Synthetic fossilization of soft biological tissues and their shape-preserving transformation into silica or electron-conductive replicas

Revealing the micromechanisms behind semi-solid metal deformation with time-resolved X-ray tomography

Progressive contraction of the latent HIV reservoir around a core of less-differentiated CD4+ memory T Cells

On-the-fly decoding luminescence lifetimes in the microsecond region for lanthanide-encoded suspension arrays

The splicing activator DAZAP1 integrates splicing control into MEK/Erk regulated cell proliferation and migration

The seco-iridoid pathway from Catharanthus roseus

Direct measurement of the upper critical field in cuprate superconductors

The emerging biofuel crop Camelina sativa retains a highly undifferentiated hexaploid genome structure

A source of antihydrogen for in-flight hyperfine spectroscopy

Permafrost thawing as a possible source of abrupt carbon release at the onset of the Bølling/Allerød

Unconventionally secreted effectors of two filamentous pathogens target plant salicylate biosynthesis

Meiofauna increases bacterial denitrification in marine sediments

Frustration-induced nanometre-scale inhomogeneity in a triangular antiferromagnet

Loss of beta2-integrin-mediated cytoskeletal linkage reprograms dendritic cells to a mature migratory phenotype

Direct synthesis of formic acid from carbon dioxide by hydrogenation in acidic media

Ultrastable cellulosome-adhesion complex tightens under load

Genome sequence of mungbean and insights into evolution within Vigna species

Autotransporters but not pAA are critical for rabbit colonization by Shiga toxin-producing Escherichia coli O104:H4

The evolution of cichlid fish egg-spots is linked with a cis-regulatory change

Ectopic A-lattice seams destabilize microtubules

Inhibition of Osteoclastogenesis and Inflammatory Bone Resorption by Targeting BET Proteins and Epigenetic Regulation

A population of glomerular glutamatergic neurons controls sensory information transfer in the mouse olfactory bulb

miRNA-based buffering of the cobblestone–lissencephaly-associated extracellular matrix receptor dystroglycan via its alternative 3′-UTR

Fabrication of crystals from single metal atoms

Morphological and population genomic evidence that human faces have evolved to signal individual identity

Dynactin functions as both a dynamic tether and brake during dynein-driven motility

The pseudogene TUSC2P promotes TUSC2 function by binding multiple microRNAs

Taking Snapshots of Photosynthetic Water Oxidation Using Femtosecond X-ray Diffraction and Spectroscopy

Genome-wide analysis of the human p53 transcriptional network unveils a lncRNA tumour suppressor signature

Direct Observation of the Three Regions in α-Synuclein that Determine its Membrane-Bound Behaviour

Development of Oculomotor Circuitry Independent of Hox3 Genes

Magnetic antibody-linked nanomatchmakers for therapeutic cell targeting

Functional characterization of the TERRA transcriptome at damaged telomeres

The stimulus-evoked population response in visual cortex of awake monkey is a propagating wave

European sea bass genome and its variation provide insights into adaptation to euryhalinity and speciation

Oncogenic Ras induces inflammatory cytokine production by up-regulating the squamous cell carcinoma antigens SerpinB3/B4

Mechanistic Insight into the Interaction of BLM helicase with Intra-strand G-quadruplex Structures

Architecture and dynamic remodeling of the septin cytoskeleton during the cell cycle

Extremely stretchable thermosensitive hydrogels by introducing slide-ring polyrotaxane cross-linkers and ionic groups into the polymer network

Multiscale structural gradients enhance the biomechanical functionality of the spider fang

MICROFLUIDIC PLATFORM FOR THE QUANTITATIVE ANALYSIS OF LEUKOCYTE MIGRATION SIGNATURES

Laminar activity in the hippocampus and entorhinal cortex related to novelty and episodic encoding

Mesoscale assembly of chemically modified graphene into complex cellular networks

Critical behaviours of contact near phase transitions

PKM2 Regulates the Warburg Effect and Promotes HMGB1 Release in Sepsis

Unravelling the effects of radiation forces in water

D-Glucosamine supplementation extends life span of nematodes and of ageing mice

Homeostatic control of polo-like kinase-1 engenders non-genetic heterogeneity in G2 checkpoint fidelity and timing

Correlated Defect Nano-Regions in a Metal–Organic Framework

Rational strategy for shaped nanomaterial synthesis in reverse micelle reactors

Coordinated regulation of photosynthesis in rice increases yield and tolerance to environmental stress

Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice

BRCA1 haploinsufficiency for replication stress suppression in primary cells

Mudskipper genomes provide insights into the terrestrial adaptation of amphibious fishes

Oscillations emerging from noise-driven steady state in networks with electrical synapses and subthreshold resonance

Practice and sleep form different aspects of skill

Cell reorientation under cyclic stretching

microRNA input into a neural ultradian oscillator controls emergence and timing of alternative cell states

Ravens notice dominance reversals among conspecifics within and outside their social group

Scaling behaviour for the water transport in nanoconfined geometries

Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2

G-protein stimulatory subunit alpha and Gq/11α G-proteins are both required to maintain quiescent stem-like chondrocytes

Imaging and steering an optical wireless nanoantenna link

The locust genome provides insight into swarm formation and long-distance flight

Photonic quasi-crystal terahertz lasers

Nitric oxide enhances Th9 cell differentiation and airway inflammation

Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors

Photo-antagonism of the GABAA receptor

Interferon regulatory factor 9 is critical for neointima formation following vascular injury

Laser light triggers increased Raman amplification in the regime of nonlinear Landaudamping

Dynamic operation of optical fibres beyond the single-mode regime facilitates the orientation of biological cells

Structure of the hexameric HerA ATPase reveals a mechanism of translocation-coupled DNA-end processing in archaea

Correlated optical and isotopic nanoscopy

Multiple haplotype-resolved genomes reveal population patterns of gene and protein diplotypes

PARP13 regulates cellular mRNA post-transcriptionally and functions as a pro-apoptotic factor by destabilizing TRAILR4 transcript

Theory of rapid force spectroscopy

Deformation-induced structural transition in body-centred cubic molybdenum

Licensing MLH1 sites for crossover during meiosis

Family-wide analysis of poly(ADP-ribose) polymerase activity

Extending medium-range predictability of extreme hydrological events in Europe

Structural signatures of dynamic heterogeneities in monolayers of colloidal ellipsoids

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

Functional annotation of colon cancer risk SNPs

Atomic electric fields revealed by a quantum mechanical approach to electron picodiffraction

Impact of oceanic-scale interactions on the seasonal modulation of ocean dynamics by the atmosphere

Guidance of subcellular tubulogenesis by actin under the control of a synaptotagmin-like protein and Moesin

A Non-inactivating High-voltage-activated Two-Pore Na+ Channel that Supports Ultra-long Action Potentials and Membrane Bistability

TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer

Diverse and divergent protein post-translational modifications in two growth stages of a natural microbial community

Reconstructing propagation networks with natural diversity and identifying hidden sources

The DUSP26 phosphatase activator adenylate kinase 2 regulates FADD phosphorylation and cell growth

Direct contribution of the seagrass Thalassia testudinum to lime mud production

The Pan-Cancer Analysis of Pseudogene Expression Reveals Biologically and Clinically Relevant Tumour Subtypes

Slow unloading leads to DNA-bound β 2-sliding clamp accumulation in live Escherichia coli cells

Human B cells induce dendritic cell maturation and favour Th2 polarization by inducing OX-40 ligand

miR-205 acts as a tumor radiosensitizer by targeting ZEB1 and Ubc13

MiR-9 promotes microglial activation by targeting MCPIP1

Quantifying quality in DNA self-assembly

Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons

Dietary cholesterol directly induces acute inflammasome-dependent intestinal inflammation

An exact arithmetic toolbox for a consistent and reproducible structural analysis of metabolic network models

Light-regulated gene repositioning in Arabidopsis

A Functional Interaction between Hippo-YAP Signaling and FoxO1 Mediates the Oxidative Stress Response

Asymmetric hetero-domain interface stabilizes a response regulator-DNA complex

Molecular architecture and the structural basis for anion interaction in prestin and SLC26 transporters

Frequent cases of RAS-mutated Down syndrome acute lymphoblastic leukaemia lack JAK2 mutations

Calcium-induced conformational changes of the regulatory domain of human mitochondrial aspartate/glutamate carriers

Emergence of single-molecular chirality from achiral reactants

Imaging atomic-level random walk of a point defect in graphene

Nucleosomal occupancy changes locally over key regulatory regions during cell differentiation and reprogramming

Encapsulation kinetics and dynamics of carbon monoxide in clathrate hydrate

Low abundance of the matrix arm of complex I in mitochondria predicts longevity inmice

Improving farming practices reduces the carbon footprint of spring wheat production

Photonic Aharonov–Bohm effect in photon–phonon interactions

Faster growth of the major prokaryotic versus eukaryotic CO2 fixers in the oligotrophic ocean

Vibrational nano-spectroscopic imaging correlating structure with intermolecular coupling and dynamics

Ice sheets as a significant source of highly reactive nanoparticulate iron to the oceans

Organizer-derived Bmp2 is required for the formation of a correct Bmp activity gradient during embryonic development

Prediction of antibiotic resistance by gene expression profiles

A designer cell-based histamine-specific human allergy profiler

Polymer collapse in miscible good solvents is a generic phenomenon driven by preferential adsorption

BMP signalling regulates the pre-implantation development of extra-embryonic cell lineages in the mouse embryo

Evolution of dominance mechanisms at a butterfly mimicry supergene

Primate evolution of the recombination regulator PRDM9

VAV-1 acts in a single interneuron to inhibit motor circuit activity in Caenorhabditis elegans

Occupancy of Tissue-Specific cis-Regulatory Modules by Otx2 and TLE/Groucho for Embryonic Head Specification

Molecular Mechanism of Mg2+-dependent gating in CorA

Actomyosin-dependent formation of the mechanosensitive talin–vinculin complex reinforces actin anchoring

Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations

TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins

Reconstructing Austronesian population history in Island Southeast Asia

Ubiquitin-proteasome system controls ciliogenesis at the initial step of axoneme extension

MinCD cell division proteins form alternating co-polymeric cytomotive filaments

High-contrast sub-millivolt inelastic X-ray scattering for nano- and mesoscale science

Eruption of a deep-sea mud volcano triggers rapid sediment movement

Unique behaviour of dinitrogen-bridgeddimolybdenum complexes bearing pincer ligand towards catalytic formation ofammonia

Retinoid X receptor α attenuates host antiviral response by suppressing type I interferon

Carrier-envelope phase-dependent high harmonic generation in the water window using few-cycle infrared pulses

Radiographic visualization of magma dynamics in an erupting volcano

Epithelial rotation promotes the global alignment of contractile actin bundles during Drosophila egg chamber elongation

Mutation rate plasticity in rifampicin resistance depends on Escherichia coli cell–cell interactions

Tousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication

An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins

Role of Rab11 in planar cell polarity and apical constriction during vertebrate neural tube closure

Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes

Cassava genome from a wild ancestor to cultivated varieties

ATM specifically mediates repair of double-strand breaks with blocked DNA ends

Sequential actions of β-catenin and Bmp pattern the oral nerve net in Nematostella vectensis

Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process

Genomic analyses of gynaecologic carcinosarcomas reveal frequent mutations in chromatin remodelling genes

A moiré deflectometer for antimatter

Omega-1 knockdown in Schistosoma mansoni eggs by lentivirus transduction reduces granuloma size in vivo

Discriminating cellular heterogeneity using microwell-based RNA cytometry

Modular structure facilitates mosaic evolution of the brain in chimpanzees and humans

Suppressing qubit dephasing using real-time Hamiltonian estimation

FtsZ-independent septal recruitment and function of cell wall remodelling enzymes in chlamydial pathogens

Phosphorylation of ARPP19 by protein kinase A prevents meiosis resumption in Xenopus oocytes

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Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice

Content Provider	PubMed Central
Author	Min, Sang H. Suzuki, Aae Stalker, Timothy J. Zhao, Liang Wang, Yuhuan Mckennan, Chris Riese, Matthew J. Guzman, Jessica F. Zhang, Suhong Lian, Lurong Joshi, Rohan Meng, Ronghua Seeholzer, Steven H. Choi, John K. Koretzky, Gary Marks, Michael S. Abrams, Charles S.
Abstract	PIKfyve is a lipid kinase that is essential for the synthesis of phosphatidylinositol-3,5-bisphosphate [PtdIns(3,5)P2], and for the regulation of membrane dynamics within the endolysosomal system in mammals. Depletion of intracellular pools of PtdIns(3,5)P2 in humans and in mice is associated with neurodegeneration and early lethality. However, the biological role of PtdIns(3,5)P2 in non-neural tissues is not well understood. Platelets are hematopoietic cells that function in a variety of physiological responses. Essential to many of these functions is the activation-dependent release of effectors from distinct storage granules - alpha granules, dense granules, and lysosomes - that derive from the endolysosomal system. Here we show that platelet-specific ablation of the PIKfyve gene in mice results in accelerated arterial thrombosis, but also unexpectedly to multiorgan defects that impair development, body mass, fertility, and survival by inducing inappropriate inflammatory responses characterized by macrophage accumulation in multiple tissues. Platelet depletion in vivo significantly impairs the progression of multiorgan defects in these mice, confirming that these defects reflect a platelet-specific process. Although PIKfyve-null platelets generate and release normal amounts of alpha granule and dense granule contents, they develop defective maturation and excessive storage of lysosomal enzymes, which are released upon platelet activation. Remarkably, impairing the secretion of lysosomes from PIKfyve-deficient platelets in vivo significantly attenuates the multiorgan defects in mice, suggesting that platelet lysosome secretion contributes to pathogenesis. Together, these results demonstrate that PIKfyve is an essential regulator for the biogenesis of platelet lysosomes, and highlight the previously unrecognized and important pathological contributions of platelet lysosomes in inflammation, arterial thrombosis, and macrophage biology.
Related Links	http://dx.doi.org/10.1038/ncomms5691
Starting Page	4691
File Format	PDF
ISSN	20411723
e-ISSN	20411723
Journal	Nature communications
Volume Number	5
Language	English
Publisher Date	2014-09-01
Access Restriction	Open
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Physics and Astronomy(all) Chemistry(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Chemistry Physics and Astronomy Biochemistry, Genetics and Molecular Biology

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