NDLI: Redox-responsive branched-bottlebrush polymers for in vivo MRI and fluorescence imaging

Content Provider	PubMed Central
Author	Sowers, Molly A. Mccombs, Jessica R. Wang, Ying Paletta, Joseph T. Morton, Stephen W. Dreaden, Erik C. Boska, Michael D. Ottaviani, M. Francesca Hammond, Paula T. Rajca, Andrzej Johnson, Jeremiah A.
Copyright Year	2014
Abstract	Stimuli-responsive multimodality imaging agents have broad potential in medical diagnostics. Herein, we report the development of a new class of branched-bottlebrush polymer dual-modality organic radical contrast agents—ORCAFluors—for combined magnetic resonance and near-infrared fluorescence imaging in vivo. These nitroxide radical-based nanostructures have longitudinal and transverse relaxation times that are on par with commonly used heavy-metal-based magnetic resonance imaging (MRI) contrast agents. Furthermore, these materials display a unique compensatory redox response: fluorescence is partially quenched by surrounding nitroxides in the native state; exposure to ascorbate or ascorbate/glutathione leads to nitroxide reduction and a concomitant 2- to 3.5-fold increase in fluorescence emission. This behaviour enables correlation of MRI contrast, fluorescence intensity and spin concentration with tissues known to possess high concentrations of ascorbate in mice. Our in vitro and in vivo results, along with our modular synthetic approach, make ORCAFluors a promising new platform for multimodality molecular imaging.
Related Links	http://dx.doi.org/10.1038/ncomms6460
Ending Page	5460
Page Count	1
Starting Page	5460
File Format	PDF
ISSN	20411723
e-ISSN	20411723
Journal	Nature communications
Volume Number	5
Language	English
Publisher Date	2014-11-01
Access Restriction	Open
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Physics and Astronomy(all) Chemistry(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Chemistry Physics and Astronomy Biochemistry, Genetics and Molecular Biology

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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