NDLI: The Opisthorchis viverrini genome provides insights into life in the bile duct

Content Provider	PubMed Central
Author	Young, Neil D. Nagarajan, Niranjan Lin, Suling Joyce Korhonen, Pasi K. Jex, Aaron R. Hall, Ross S. Helena, Safavi-hemami Kaewkong, Worasak Bertrand, Denis Gao, Song Seet, Qihui Wongkham, Sopit Teh, Bin Tean Wongkham, Chaisiri Intapan, Pewpan Maleewong Maleewong, Wanchai Yang, Xinhua Hu, Min Wang, Zuo Hofmann, Andreas Sternberg, Paul W. Tan, Patrick Wang, Jun Gasser, Robin B.
Copyright Year	2014
Abstract	Opisthorchiasis is a neglected, tropical disease caused by the carcinogenic Asian liver fluke, Opisthorchis viverrini. This hepatobiliary disease is linked to malignant cancer (cholangiocarcinoma, CCA) and affects millions of people in Asia. No vaccine is available, and only one drug (praziquantel) is used against the parasite. Little is known about O. viverrini biology and the diseases that it causes. Here we characterize the draft genome (634.5 Mb) and transcriptomes of O. viverrini, elucidate how this fluke survives in the hostile environment within the bile duct and show that metabolic pathways in the parasite are highly adapted to a lipid-rich diet from bile and/or cholangiocytes. We also provide additional evidence that O. viverrini and other flukes secrete proteins that directly modulate host cell proliferation. Our molecular resources now underpin profound explorations of opisthorchiasis/CCA and the design of new interventions.
Related Links	http://dx.doi.org/10.1038/ncomms5378
Starting Page	4378
File Format	PDF
ISSN	20411723
e-ISSN	20411723
Journal	Nature Communications
Volume Number	5
Language	English
Publisher	Nature Pub. Group
Publisher Date	2014-07-01
Access Restriction	Open
Rights Holder	Nature Pub. Group
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Physics and Astronomy(all) Chemistry(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Chemistry Physics and Astronomy Biochemistry, Genetics and Molecular Biology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
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