NDLI: Mudskipper genomes provide insights into the terrestrial adaptation of amphibious fishes

Content Provider	PubMed Central
Author	You, Xinxin Bian, Chao Zan, Qijie Xu, Xun Liu, Xin Chen, Jieming Wang, Jintu Qiu, Ying Li, Wujiao Zhang, Xinhui Sun, Ying Chen, Shixi Hong, Wanshu Li, Yuxiang Cheng, Shifeng Fan, Guangyi Shi, Chengcheng Liang, Jie Tang, Y. Tom Yang, Chengye Ruan, Zhiqiang Bai, Jie Peng, Chao Mu, Qian Lu, Jun Fan, Mingjun Yang, Shuang Huang, Zhiyong Jiang, Xuanting Fang, Xiaodong Zhang, Guojie Zhang, Yong Polgar, Gianluca Yu, Hui Li, Jia Liu, Zhongjian Zhang, Guoqiang Ravi, Vydianathan Coon, Steven L. Wang, Jian Yang, Huanming Venkatesh, Byrappa Wang, Jun Shi, Qiong
Copyright Year	2014
Abstract	Mudskippers are amphibious fishes that have developed morphological and physiological adaptations to match their unique lifestyles. Here we perform whole-genome sequencing of four representative mudskippers to elucidate the molecular mechanisms underlying these adaptations. We discover an expansion of innate immune system genes in the mudskippers that may provide defence against terrestrial pathogens. Several genes of the ammonia excretion pathway in the gills have experienced positive selection, suggesting their important roles in mudskippers’ tolerance to environmental ammonia. Some vision-related genes are differentially lost or mutated, illustrating genomic changes associated with aerial vision. Transcriptomic analyses of mudskippers exposed to air highlight regulatory pathways that are up- or down-regulated in response to hypoxia. The present study provides a valuable resource for understanding the molecular mechanisms underlying water-to-land transition of vertebrates.
Related Links	http://dx.doi.org/10.1038/ncomms6594
Starting Page	5594
File Format	PDF
ISSN	20411723
e-ISSN	20411723
Journal	Nature Communications
Volume Number	5
Language	English
Publisher	Nature Pub. Group
Publisher Date	2014-12-01
Access Restriction	Open
Rights Holder	Nature Pub. Group
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Physics and Astronomy(all) Chemistry(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Chemistry Physics and Astronomy Biochemistry, Genetics and Molecular Biology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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