NDLI: Alteration of Loperamide-Induced Prostate Relaxation in High-Fat Diet-Fed Rats

Content Provider	PubMed Central
Author	Hsu, Sheng-lung Chung, Hsien-hui Chen, I-hung Tong, Yat-ching
Copyright Year	2014
Abstract	Objective. To investigate the change of loperamide-induced prostate relaxation in rats fed with high-fat diet (HFD). Materials and Methods. Adult male Wistar rats were divided into 2 groups: (1) control rats fed with normal chow and (2) rats fed with HFD for 6 months. The prostate was removed for histology study. Isolated prostate strips were hung in organ bath and precontracted with 1 μmol/L phenylephrine or 50 mmol/L KCl. The relaxation responses to loperamide 0.1 to 10 μmol/L were recorded. Western blotting analyses were performed for prostate μ-opioid receptors (MOR) and ATP-sensitive potassium (KATP) channel proteins: sulfonylurea receptor (SUR) and inwardly rectifying potassium channel (Kir) 6.2 subunits. Results. Body weight, prostate weight, plasma levels of glucose, insulin, triglyceride, and cholesterol, as well as systolic blood pressure, were significantly increased in the HFD rats. Histology showed prostatic hyperplasia in the HFD rat prostate. Prostatic relaxation induced by loperamide was markedly reduced in HFD when compared to the control. Protein expressions of MOR, SUR, and Kir 6.2 were decreased in HFD-fed rats. Conclusion. Loperamide-induced prostate relaxation is decreased in HFD rats due to reduced MOR and KATP channel expressions.
Related Links	http://dx.doi.org/10.1155/2014/517836
Starting Page	517836
File Format	PDF
ISSN	1537744X
e-ISSN	1537744X
Journal	The Scientific World Journal
Volume Number	2014
Language	English
Publisher	Hindawi Publishing Corporation
Publisher Date	2014-01-01
Access Restriction	Open
Rights Holder	Hindawi Publishing Corporation
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry, Genetics and Molecular Biology Environmental Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Alteration of Loperamide-Induced Prostate Relaxation in High-Fat Diet-Fed Rats

Prostatic Relaxation Induced by Loperamide Is Reduced in Spontaneously Hypertensive Rats

Effect of High Intensity Interval and Continuous Swimming Training on Body Mass Adiposity Level and Serum Parameters in High-Fat Diet Fed Rats

Ameliorative Potential of Tamarindus indica on High Fat Diet Induced Nonalcoholic Fatty Liver Disease in Rats

Catechin-rich green tea extract increases serum cholesterol levels in normal diet- and high fat diet-fed rats

Telmisartan prevents high-fat diet-induced hypertension and decreases perirenal fat in rats

Enhanced circulating PCSK9 concentration by berberine through SREBP-2 pathway in high fat diet-fed rats

Effects of leptin on histomorphometry of liver in high-fat diet fed obese rats

Effects of leptin on histomorphometry of liver in high-fat diet fed obese rats

Alteration of Loperamide-Induced Prostate Relaxation in High-Fat Diet-Fed Rats

Similar Documents

Alteration of Loperamide-Induced Prostate Relaxation in High-Fat Diet-Fed Rats

Prostatic Relaxation Induced by Loperamide Is Reduced in Spontaneously Hypertensive Rats

Effect of High Intensity Interval and Continuous Swimming Training on Body Mass Adiposity Level and Serum Parameters in High-Fat Diet Fed Rats

Ameliorative Potential of Tamarindus indica on High Fat Diet Induced Nonalcoholic Fatty Liver Disease in Rats

Catechin-rich green tea extract increases serum cholesterol levels in normal diet- and high fat diet-fed rats

Telmisartan prevents high-fat diet-induced hypertension and decreases perirenal fat in rats

Enhanced circulating PCSK9 concentration by berberine through SREBP-2 pathway in high fat diet-fed rats

Effects of leptin on histomorphometry of liver in high-fat diet fed obese rats

Effects of leptin on histomorphometry of liver in high-fat diet fed obese rats

Alteration of Loperamide-Induced Prostate Relaxation in High-Fat Diet-Fed Rats