NDLI: CCR5 Controls Immune and Metabolic Functions during Toxoplasma gondii Infection

Content Provider	PubMed Central
Author	Bonfá, Giuliano Benevides, Luciana Souza, Maria Do Carmo Fonseca, Denise Morais Mineo, Tiago Wilson Patriarca Rossi, Marcos Antônio Silva, Neide Maria Silva, João Santana Cardoso, Cristina Ribeiro De Barros
Editor	Heimesaat, Markus M.
Copyright Year	2014
Abstract	CCR5, an important receptor related to cell recruitment and inflammation, is expressed during experimental Toxoplasma gondii infection. However, its role in the immunopathology of toxoplasmosis is not clearly defined yet. Thus, we inoculated WT and CCR5-/- mice with a sub lethal dose of the parasite by oral route. CCR5-/- mice were extremely susceptible to infection, presenting higher parasite load and lower tissue expression of IL-12p40, IFN-γ, TNF, IL-6, iNOS, Foxp3, T-bet, GATA-3 and PPARα. Although both groups presented inflammation in the liver with prominent neutrophil infiltration, CCR5-/- mice had extensive tissue damage with hepatocyte vacuolization, steatosis, elevated serum triglycerides and transaminases. PPARα agonist Gemfibrozil improved the vacuolization but did not rescue CCR5-/- infected mice from high serum triglycerides levels and enhanced mortality. We also found intense inflammation in the ileum of CCR5-/- infected mice, with epithelial ulceration, augmented CD4 and decreased frequency of NK cells in the gut lamina propria. Most interestingly, these findings were accompanied by an outstanding accumulation of neutrophils in the ileum, which seemed to be involved in the gut immunopathology, once the depletion of these cells was accompanied by reduced local damage. Altogether, these data demonstrated that CCR5 is essential to the control of T. gondii infection and to maintain the metabolic, hepatic and intestinal integrity. These findings add novel information on the disease pathogenesis and may be relevant for directing future approaches to the treatment of multi-deregulated diseases.
Related Links	http://dx.doi.org/10.1371/journal.pone.0104736
Starting Page	104736
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	8
Volume Number	9
Language	English
Publisher	Public Library of Science
Publisher Date	2014-08-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Pyrimidinergic Receptor Activation Controls Toxoplasma gondii Infection in Macrophages

Identification of Toxoplasma gondii Genes Responsive to the Host Immune Response during In Vivo Infection

Anti-Gluten Immune Response following Toxoplasma gondii Infection in Mice

Subcellular Antigen Location Influences T-Cell Activation during Acute Infection with Toxoplasma gondii

GITR Activation Positively Regulates Immune Responses against Toxoplasma gondii

MIF Participates in Toxoplasma gondii-Induced Pathology Following Oral Infection

Proteomic Profiling of Mouse Liver following Acute Toxoplasma gondii Infection

Seroepidemiology of Toxoplasma gondii Infection among Healthy Blood Donors in Taiwan

IL-21 Is Required for Optimal Antibody Production and T Cell Responses during Chronic Toxoplasma gondii Infection

CCR5 Controls Immune and Metabolic Functions during Toxoplasma gondii Infection

Similar Documents

Pyrimidinergic Receptor Activation Controls Toxoplasma gondii Infection in Macrophages

Identification of Toxoplasma gondii Genes Responsive to the Host Immune Response during In Vivo Infection

Anti-Gluten Immune Response following Toxoplasma gondii Infection in Mice

Subcellular Antigen Location Influences T-Cell Activation during Acute Infection with Toxoplasma gondii

GITR Activation Positively Regulates Immune Responses against Toxoplasma gondii

MIF Participates in Toxoplasma gondii-Induced Pathology Following Oral Infection

Proteomic Profiling of Mouse Liver following Acute Toxoplasma gondii Infection

Seroepidemiology of Toxoplasma gondii Infection among Healthy Blood Donors in Taiwan

IL-21 Is Required for Optimal Antibody Production and T Cell Responses during Chronic Toxoplasma gondii Infection

CCR5 Controls Immune and Metabolic Functions during Toxoplasma gondii Infection