NDLI: Pulmonary vascular distensibility predicts aerobic capacity in healthy individuals

Content Provider	PubMed Central
Author	Lalande, Sophie Yerly, Patrick Faoro, Vitalie Robert, Naeije
Copyright Year	2012
Abstract	It has been suggested that shallow slopes of mean pulmonary artery pressure (MPPA)–cardiac output ( ) relationships and pulmonary transit of agitated contrast during exercise may be associated with a higher maximal aerobic capacity ( ). If so, individuals with a higher could also exhibit a higher pulmonary vascular distensibility and increased pulmonary capillary blood volume during exercise. Exercise stress echocardiography was performed with repetitive injections of agitated contrast and measurements of MPPA, and lung diffusing capacities for carbon monoxide (D L,CO) and nitric oxide (D L,NO) in 24 healthy individuals. A pulmonary vascular distensibility coefficient α was mathematically determined from the slight natural curvilinearity of multipoint MPPA– plots. Membrane (D m) and capillary blood volume (V c) components of lung diffusing capacity were calculated. Maximal exercise increased MPPA, cardiac index (CI), D L,CO and D L,NO. The slope of the linear best fit of MPPA–CI was 3.2 ± 0.5 mmHg min l−1 m2 and α was 1.1 ± 0.3% mmHg−1. A multivariable analysis showed that higher α and greater V c independently predicted . All individuals had markedly positive pulmonary transit of agitated contrast at maximal exercise, with increases proportional to increases in pulmonary capillary pressure and V c. Pulmonary transit of agitated contrast was not related to pulse oximetry arterial oxygen saturation. Therefore, a more distensible pulmonary circulation and a greater pulmonary capillary blood volume are associated with a higher in healthy individuals. Agitated contrast commonly transits through the pulmonary circulation at exercise, in proportion to increased pulmonary capillary pressures.
Related Links	http://dx.doi.org/10.1113/jphysiol.2012.234310
Ending Page	4288
Page Count	10
Starting Page	4279
File Format	PDF
ISSN	00223751
e-ISSN	14697793
Journal	The Journal of Physiology
Issue Number	Pt 17
Volume Number	590
Language	English
Publisher	Blackwell Science Inc
Publisher Date	2012-09-01
Access Restriction	Open
Rights Holder	Blackwell Science Inc
Subject Keyword	Physiology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Physiology Sports Science

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