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| Content Provider | PubMed Central |
|---|---|
| Author | Ivan, Bogeski Tatiana, Kilch Niemeyer, Barbara A. |
| Copyright Year | 2012 |
| Abstract | Store-operated Ca2+ entry (SOCE) is a widespread mechanism in cells to raise cytosolic Ca2+ and to refill Ca2+ stores. T cells critically rely on SOCE mediated by stromal interaction molecules (STIM) and Orai molecules for their activation and regulation of gene transcription; cells such as muscle cells, neurons or melanocytes probably utilize SOCE for the transmission of inducible receptor-mediated function as well as for generalized Ca2+ homeostasis mechanisms. Exposure to environmental or cell-intrinisic reactive oxygen species (ROS) can affect several components involved in Ca2+ homeostasis and thus alter multiple pathways. While all cells have a capacity to produce intracellular ROS, exposure of immune and skin cells to extracellular oxidative stress is particularly high during inflammation and/or with UV exposure. This review briefly summarizes cell-intrinsic sources of ROS and focuses on current findings and controversies regarding the regulation of STIM and Orai by oxidative modifications. We also introduce melanocytes as a new model system to study the function of STIM and Orai isoforms under physiological conditions that include exposure to UV light as an activating stimulus. |
| Related Links | http://dx.doi.org/10.1113/jphysiol.2012.230565 |
| Starting Page | 4193 |
| File Format | |
| ISSN | 14697793 |
| e-ISSN | 14697793 |
| Journal | The Journal of Physiology |
| Issue Number | Pt 17 |
| Volume Number | 590 |
| Language | English |
| Publisher | Blackwell Science Inc |
| Publisher Date | 2012-09-01 |
| Access Restriction | Open |
| Rights Holder | Blackwell Science Inc |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Sports Science |
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