NDLI: Effect of ageing on left ventricular compliance and distensibility in healthy sedentary humans

Content Provider	PubMed Central
Author	Fujimoto, Naoki Hastings, Jeffrey L. Bhella, Paul S. Shibata, Shigeki Gandhi, Nainesh K. Graeme, Carrick-ranson Palmer, Dean Levine, Benjamin D.
Copyright Year	2012
Abstract	Healthy, but sedentary ageing leads to marked atrophy and stiffening of the heart, with substantially reduced cardiac compliance; but the time course of when this process occurs during normal ageing is unknown. Seventy healthy sedentary subjects (39 female; 21–77 years) were recruited from the Dallas Heart Study, a population-based, random community sample and enriched by a second random sample from employees of Texas Health Resources. Subjects were highly screened for co-morbidities and stratified into four groups according to age: G21−34: 21–34 years, G35−49: 35–49 years, G50−64: 50–64 years, G≥65: ≥65 years. All subjects underwent invasive haemodynamic measurements with right heart catheterization to define Starling and left ventricular (LV) pressure–volume curves. LV end-diastolic volumes (EDV) were measured by echocardiography at baseline, −15 and −30 mmHg lower-body negative pressure, and 15 and 30 ml kg−1 saline infusion with simultaneous measurements of pulmonary capillary wedge pressure. There were no differences in heart rate or blood pressures among the four groups at baseline. Baseline EDV index was smaller in G≥65 than other groups. LV diastolic pressure–volume curves confirmed a substantially greater LV compliance in G21−34 compared with G50−64 and G≥65, resulting in greater LV volume changes with preload manipulations. Although LV chamber compliance in G50−64 and G≥65 appeared identical, pressure–volume curves were shifted leftward, toward a decreased distensibility, with increasing age. These results suggest that LV stiffening in healthy ageing occurs during the transition between youth and middle-age and becomes manifest between the ages of 50 to 64. Thereafter, this LV stiffening is followed by LV volume contraction and remodelling after the age of 65.
Related Links	http://dx.doi.org/10.1113/jphysiol.2011.218271
Ending Page	1880
Page Count	10
Starting Page	1871
File Format	PDF
ISSN	00223751
e-ISSN	14697793
Journal	The Journal of Physiology
Issue Number	Pt 8
Volume Number	590
Language	English
Publisher	Blackwell Science Inc
Publisher Date	2012-04-15
Access Restriction	Open
Rights Holder	Blackwell Science Inc
Subject Keyword	Physiology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Physiology Sports Science

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