NDLI: Serological Evidence of Ebola Virus Infection in Indonesian Orangutans

Content Provider	PubMed Central
Author	Nidom, Chairul A. Nakayama, Eri Nidom, Reviany V. Alamudi, Mohamad Y. Daulay, Syafril Dharmayanti, Indi N. L. P. Dachlan, Yoes P. Amin, Mohamad Igarashi, Manabu Miyamoto, Hiroko Yoshida, Reiko Takada, Ayato
Editor	Bausch, Daniel G.
Copyright Year	2012
Abstract	Ebola virus (EBOV) and Marburg virus (MARV) belong to the family Filoviridae and cause severe hemorrhagic fever in humans and nonhuman primates. Despite the discovery of EBOV (Reston virus) in nonhuman primates and domestic pigs in the Philippines and the serological evidence for its infection of humans and fruit bats, information on the reservoirs and potential amplifying hosts for filoviruses in Asia is lacking. In this study, serum samples collected from 353 healthy Bornean orangutans (Pongo pygmaeus) in Kalimantan Island, Indonesia, during the period from December 2005 to December 2006 were screened for filovirus-specific IgG antibodies using a highly sensitive enzyme-linked immunosorbent assay (ELISA) with recombinant viral surface glycoprotein (GP) antigens derived from multiple species of filoviruses (5 EBOV and 1 MARV species). Here we show that 18.4% (65/353) and 1.7% (6/353) of the samples were seropositive for EBOV and MARV, respectively, with little cross-reactivity among EBOV and MARV antigens. In these positive samples, IgG antibodies to viral internal proteins were also detected by immunoblotting. Interestingly, while the specificity for Reston virus, which has been recognized as an Asian filovirus, was the highest in only 1.4% (5/353) of the serum samples, the majority of EBOV-positive sera showed specificity to Zaire, Sudan, Cote d’Ivoire, or Bundibugyo viruses, all of which have been found so far only in Africa. These results suggest the existence of multiple species of filoviruses or unknown filovirus-related viruses in Indonesia, some of which are serologically similar to African EBOVs, and transmission of the viruses from yet unidentified reservoir hosts into the orangutan populations. Our findings point to the need for risk assessment and continued surveillance of filovirus infection of human and nonhuman primates, as well as wild and domestic animals, in Asia.
Related Links	http://dx.doi.org/10.1371/journal.pone.0040740
Starting Page	40740
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	7
Volume Number	7
Language	English
Publisher	Public Library of Science
Publisher Date	2012-07-18
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Expression of Concern: Serological Evidence of Ebola Virus Infection in Indonesian Orangutans

Ebola virus-like particles protect from lethal Ebola virus infection

Serological Evidence of Ebola Virus Infection in Rural Guinea before the 2014 West African Epidemic Outbreak.

Serological Evidence of Infection with Sendai Virus in England

Serological Evidence of Filovirus Infection in Nonhuman Primates in Zambia

Cytomegalovirus-based vaccine expressing Ebola virus glycoprotein protects nonhuman primates from Ebola virus infection

Serological evidence of bovine immunodeficiency-like virus infection in a sheep.

Serological evidence of hepatitis E virus infection in an indigenous North American population

Human Ebola virus infection results in substantial immune activation

Serological Evidence of Ebola Virus Infection in Indonesian Orangutans

Similar Documents

Expression of Concern: Serological Evidence of Ebola Virus Infection in Indonesian Orangutans

Ebola virus-like particles protect from lethal Ebola virus infection

Serological Evidence of Ebola Virus Infection in Rural Guinea before the 2014 West African Epidemic Outbreak.

Serological Evidence of Infection with Sendai Virus in England

Serological Evidence of Filovirus Infection in Nonhuman Primates in Zambia

Cytomegalovirus-based vaccine expressing Ebola virus glycoprotein protects nonhuman primates from Ebola virus infection

Serological evidence of bovine immunodeficiency-like virus infection in a sheep.

Serological evidence of hepatitis E virus infection in an indigenous North American population

Human Ebola virus infection results in substantial immune activation

Serological Evidence of Ebola Virus Infection in Indonesian Orangutans