NDLI: Comparative Genome Analysis of the High Pathogenicity Salmonella Typhimurium Strain UK-1

Content Provider	PubMed Central
Author	Luo, Yingqin Kong, Qingke Yang, Jiseon Mitra, Arindam Golden, Greg Wanda, Soo-young Roland, Kenneth L. Jensen, Roderick V. Ernst, Peter B. Curtiss, Roy
Editor	Jean-pierre, Gorvel
Copyright Year	2012
Abstract	Salmonella enterica serovar Typhimurium, a gram-negativefacultative rod-shaped bacterium causing salmonellosis and foodborne disease,is one of the most common isolated Salmonella serovars inboth developed and developing nations. Several S. Typhimuriumgenomes have been completed and many more genome-sequencing projects are underway.Comparative genome analysis of the multiple strains leads to a better understandingof the evolution of S. Typhimurium and its pathogenesis. S.Typhimurium strain UK-1 (belongs to phage type 1) is highly virulent whenorally administered to mice and chickens and efficiently colonizes lymphoidtissues of these species. These characteristics make this strain a good choicefor use in vaccine development. In fact, UK-1 has been used as the parentstrain for a number of nonrecombinant and recombinant vaccine strains, includingseveral commercial vaccines for poultry. In this study, we conducted a thoroughcomparative genome analysis of the UK-1 strain with other S.Typhimurium strains and examined the phenotypic impact of several genomicdifferences. Whole genomic comparison highlights an extremely close relationshipbetween the UK-1 strain and other S. Typhimurium strains;however, many interesting genetic and genomic variations specific to UK-1were explored. In particular, the deletion of a UK-1-specific gene that ishighly similar to the gene encoding the T3SS effector protein NleC exhibiteda significant decrease in oral virulence in BALB/c mice. The complete geneticcomplements in UK-1, especially those elements that contribute to virulenceor aid in determining the diversity within bacterial species, provide keyinformation in evaluating the functional characterization of important geneticdeterminants and for development of vaccines.
Related Links	http://dx.doi.org/10.1371/journal.pone.0040645
Starting Page	40645
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	7
Volume Number	7
Language	English
Publisher	Public Library of Science
Publisher Date	2012-07-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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