NDLI: Haplotype Affinities Resolve a Major Component of Goat (Capra hircus) MtDNA D-Loop Diversity and Reveal Specific Features of the Sardinian Stock

Content Provider	PubMed Central
Author	Piras, Daniela Doro, Maria Grazia Casu, Giuseppina Melis, Paola Maria Simona, Vaccargiu Piras, Ignazio Parracciani, Debora Roberta, Stradoni Bruno, Frongia Lai, Graziano Sale, Salvatore Walter, Cattari Piras, Roberto Querci, Ombretta Demuro, Piergiorgio Cui, Sandro Atzori, Franco Mancosu, Marco Marchiori, Francesca Cammelli, Rossana Spiga, Alessandra Loddo, Pier Paolo Pili, Gianfranco Boi, Roberto Argiolas, Giuseppe Mereu, Paolo Leoni, Giovanni Giuseppe Salvatore, Naitana Mario, Pirastu Andrea, Novelletto
Editor	Dan, Mishmar
Copyright Year	2012
Abstract	Goat mtDNA haplogroup A is a poorly resolved lineage absorbing most of the overall diversity and is found in locations as distant as Eastern Asia and Southern Africa. Its phylogenetic dissection would cast light on an important portion of the spread of goat breeding. The aims of this work were 1) to provide an operational definition of meaningful mtDNA units within haplogroup A, 2) to investigate the mechanisms underlying the maintenance of diversity by considering the modes of selection operated by breeders and 3) to identify the peculiarities of Sardinian mtDNA types. We sequenced the mtDNA D-loop in a large sample of animals (1,591) which represents a non-trivial quota of the entire goat population of Sardinia. We found that Sardinia mirrors a large quota of mtDNA diversity of Western Eurasia in the number of variable sites, their mutational pattern and allele frequency. By using Bayesian analysis, a distance-based tree and a network analysis, we recognized demographically coherent groups of sequences identified by particular subsets of the variable positions. The results showed that this assignment system could be reproduced in other studies, capturing the greatest part of haplotype diversity.
Related Links	http://dx.doi.org/10.1371/journal.pone.0030785
Starting Page	30785
File Format	PDF
ISSN	19326203
e-ISSN	19326203
Journal	PLoS ONE
Issue Number	2
Volume Number	7
Language	English
Publisher	Public Library of Science
Publisher Date	2012-02-01
Access Restriction	Open
Rights Holder	Public Library of Science
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Agricultural and Biological Sciences(all) Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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