NDLI: Exploring the Cellular Accumulation of Metal Complexes

Content Provider	PubMed Central
Author	Puckett, Cindy A. Ernst, Russell J. Barton, Jacqueline K.
Abstract	Transition metal complexes offer great potential as diagnostic and therapeutic agents, and a growing number of biological applications have been explored. To be effective, these complexes must reach their intended target inside the cell. Here we review the cellular accumulation of metal complexes, including their uptake, localization, and efflux. Metal complexes are taken up inside cells through various mechanisms, including passive diffusion and entry through organic and metal transporters. Emphasis is placed on the methods used to examine cellular accumulation, to identify the mechanism(s) of uptake, and to monitor possible efflux. Conjugation strategies that have been employed to improve the cellular uptake characteristics of metal complexes are also described.
Related Links	http://dx.doi.org/10.1039/b922209j
Ending Page	1170
Page Count	12
Starting Page	1159
File Format	PDF
ISSN	14779226
e-ISSN	14779234
Journal	Dalton transactions (Cambridge, England : 2003)
Issue Number	5
Volume Number	39
Language	English
Publisher Date	2010-01-01
Access Restriction	Open
Subject Keyword	Inorganic Chemistry Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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Exploring the Cellular Accumulation of Metal Complexes