NDLI: Targeted Chemotherapy with Metal Complexes

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Targeted Chemotherapy with Metal Complexes

Content Provider	PubMed Central
Author	Weidmann, Alyson G. Komor, Alexis C. Barton, Jacqueline K.
Abstract	Classical chemotherapeutics, such as cisplatin and its analogues, have been highly successful in the clinic, yet improvements can certainly be made, given the significant side effects associated with the killing of healthy cells. Recent advances in the field of chemotherapy include the development of targeted anticancer agents, compounds that are directed towards a specific biomarker of cancer, with the hopes that such targeted therapies might have reduced side effects given their greater selectivity. Here we discuss several transition metal complexes that are tailored towards various biomolecules associated with cancer. Most notably, the success of rhodium metalloinsertors, which specifically bind to nucleic acid base mismatches in DNA, highlight the enormous potential of this exciting new strategy.
Related Links	http://dx.doi.org/10.1080/02603594.2014.890099
Ending Page	123
Page Count	10
Starting Page	114
File Format	PDF
ISSN	02603594
e-ISSN	15489574
Journal	Comments on modern chemistry. Part A, Comments on inorganic chemistry : a journal of critical discussion of the current literature
Issue Number	3-4
Volume Number	34
Language	English
Publisher Date	2014-05-04
Access Restriction	Open
Subject Keyword	Inorganic Chemistry Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Inorganic Chemistry

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