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  1. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
  2. Year: 2010, Volume: 15
  3. Year: 2010, Volume: 15, Issue: 7
  4. THE EFFECT OF PHOSPHATE ACCUMULATION ON METAL ION HOMEOSTASIS IN SACCHAROMYCES CEREVISIAE
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Year: 2015, Volume: 20
Year: 2014, Volume: 19
Year: 2013, Volume: 18
Year: 2012, Volume: 17
Year: 2011, Volume: 16
Year: 2010, Volume: 15
Year: 2010, Volume: 15, Issue: 8
Year: 2010, Volume: 15, Issue: 7
THE EFFECT OF PHOSPHATE ACCUMULATION ON METAL ION HOMEOSTASIS IN SACCHAROMYCES CEREVISIAE
Spectroscopic insights into axial ligation and active-site H-bonding in substrate-bound human heme oxygenase-2
Year: 2010, Volume: 15, Issue: 6
Year: 2010, Volume: 15, Issue: 5
Year: 2010, Volume: 15, Issue: 4
Year: 2010, Volume: 15, Issue: 2
Year: 2009, Volume: 14 Suppl 1
Year: 2009, Volume: 14
Year: 2008, Volume: 13
Year: 2007, Volume: 12
Year: 2004, Volume: 9

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THE EFFECT OF PHOSPHATE ACCUMULATION ON METAL ION HOMEOSTASIS IN SACCHAROMYCES CEREVISIAE

Content Provider PubMed Central
Author Rosenfeld, Leah Reddi, Amit R. Leung, Edison Aranda, Kimberly Jensen, Laran T. Culotta, Valeria C.
Abstract Much of what is currently understood about the cell biology of metals involves their interactions with proteins. By comparison, little is known about metal interactions with intracellular inorganic compounds such as phosphate. Here we examined the role of phosphate in metal metabolism in vivo by genetically perturbing the phosphate content of Saccharomyces cerevisiae cells. Yeast pho80 mutants cannot sense phosphate and have lost control of phosphate uptake, storage and metabolism. We report here that pho80 mutants specifically elevate cytosolic and non-vacuolar phosphate and this in turn causes a wide range of metal homeostasis defects. Intracellular levels of the hard metal cations sodium and calcium increase dramatically, and cells become susceptible to toxicity from the transition metals manganese, cobalt, zinc and copper. Disruptions in phosphate control also elicit an iron starvation response, as pho80 mutants were seen to up-regulate iron transport genes. The iron responsive transcription factor Aft1p appears activated in cells with high phosphate in spite of normal intracellular iron levels. The high phosphate of pho80 mutants can be lowered by mutating Pho4p, the transcription factor for phosphate uptake and storage genes. Such lowering of phosphate by pho4 mutations reversed the high calcium and sodium of pho80 mutants and prevented the iron starvation response. However, pho4 mutations only partially reversed toxicity from heavy metals, representing a novel outcome of phosphate dysregulation. Overall these studies underscore the importance of maintaining a charge balance in the cell; a disruption in phosphate metabolism can dramatically impact on metal homeostasis.
Related Links http://dx.doi.org/10.1007/s00775-010-0664-8
Ending Page 1062
Page Count 12
Starting Page 1051
File Format PDF
ISSN 09498257
e-ISSN 14321327
Journal Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
Issue Number 7
Volume Number 15
Language English
Publisher Date 2010-09-01
Access Restriction Open
Subject Keyword Inorganic Chemistry Biochemistry Research in Higher Education
Content Type Text
Resource Type Article
Subject Biochemistry Inorganic Chemistry
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