NDLI: Non-linear, high-gain and sustained-to-transient signal transmission from rods to amacrine cells in dark-adapted retina of Ambystoma

Content Provider	PubMed Central
Author	Yang, Xiong-li Gao, Fan Wu, Samuel M.
Copyright Year	2002
Abstract	In darkness, On-Off amacrine cells (ACs) of the tiger salamander retina exhibited large spontaneous transient depolarizing potentials (sTDPs) with average peak amplitude of 5.05 ± 2.5 mV and average frequency of 0.42 ± 0.25 s−1. Under voltage-clamp conditions the cell displayed large spontaneous postsynaptic currents (sPSCs) with average peak amplitude of 98 ± 39 pA and average frequency of 0.45 ± 0.22 s−1. To a light step, ACs gave rise to a transient ‘On’ response at the light onset and a transient ‘Off’ response at light offset, followed by a train of TDPs (‘After’ response). Near the response threshold (0.3 activated rhodopsin molecules per rod per second), light-evoked TDPs (leTDPs) of similar amplitude and kinetics as the large sTDPs observed in darkness were seen, and about half of these leTDPs elicited a regenerative potential (RP). Brighter light steps gave rise to more leTDPs and higher rates of RPs in the On, Off and After responses. Within the linear response range of the rods, the AC response was non-linear, with the highest gain (676 ± 429) near the dark potential. The amplitude of Off responses increased with the duration of the light step, and ACs may use this to encode speeds of moving stimuli: the faster the light object moves, the smaller the AC Off response. Moreover, the number of leTDPs in the AC After response increased with light intensity, and the onset of the After response coincides with bipolar cell tail response recovery. One possible origin of the large sTDPs and leTDPs is the spontaneous and depolarization-induced regenerative calcium potentials (RCaPs) in bipolar cell synaptic terminals. RCaPs in bipolar cell synaptic terminals cause transient glutamate release that results in the sTDPs in darkness, and leTDPs in On, Off and After responses in ACs.
Related Links	http://dx.doi.org/10.1113/jphysiol.2001.013110
Ending Page	251
Page Count	13
Starting Page	239
File Format	PDF
ISSN	00223751
e-ISSN	14697793
Journal	The Journal of Physiology
Issue Number	Pt 1
Volume Number	539
Language	English
Publisher	Blackwell Science Inc
Publisher Date	2002-02-01
Access Restriction	Open
Rights Holder	Blackwell Science Inc
Subject Keyword	Physiology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Physiology Sports Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Linear transduction of natural stimuli by dark-adapted and light-adapted rods of the salamander, Ambystoma tigrinum.

Light-evoked current responses in rod bipolar cells, cone depolarizing bipolar cells and all amacrine cells in dark-adapted mouse retina

Signal transmission through the dark-adapted retina of the toad (Bufo marinus). Gain, convergence, and signal/noise

The photovoltage of rods and cones in the dark-adapted mouse retina

Signal transmission from rods to ganglion cells in rat retina after bleaching a portion of the receptive field.

Switching between transient and sustained signalling at the rod bipolar-AII amacrine cell synapse of the mouse retina

The calcium current in inner segments of rods from the salamander (Ambystoma tigrinum) retina.

Voltage gain of signal transfer from retinal rods to bipolar cells in the tiger salamander.

Control of the generator current in solitary rods of the Ambystoma tigrinum retina.

Non-linear, high-gain and sustained-to-transient signal transmission from rods to amacrine cells in dark-adapted retina of Ambystoma

Similar Documents

Linear transduction of natural stimuli by dark-adapted and light-adapted rods of the salamander, Ambystoma tigrinum.

Light-evoked current responses in rod bipolar cells, cone depolarizing bipolar cells and all amacrine cells in dark-adapted mouse retina

Signal transmission through the dark-adapted retina of the toad (Bufo marinus). Gain, convergence, and signal/noise

The photovoltage of rods and cones in the dark-adapted mouse retina

Signal transmission from rods to ganglion cells in rat retina after bleaching a portion of the receptive field.

Switching between transient and sustained signalling at the rod bipolar-AII amacrine cell synapse of the mouse retina

The calcium current in inner segments of rods from the salamander (Ambystoma tigrinum) retina.

Voltage gain of signal transfer from retinal rods to bipolar cells in the tiger salamander.

Control of the generator current in solitary rods of the Ambystoma tigrinum retina.

Non-linear, high-gain and sustained-to-transient signal transmission from rods to amacrine cells in dark-adapted retina of Ambystoma