NDLI: Characterization of the functional properties of env genes from long-term survivors of human immunodeficiency virus type 1 infection.

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Frequency of multiple Epstein-Barr virus infections in T-cell-immunocompromised individuals.

Isolation of intertypic recombinants of Epstein-Barr virus from T-cell-immunocompromised individuals.

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Self-deleting retrovirus vectors for gene therapy.

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Detection of simian immunodeficiency virus (SIV)-specific CD8+ T cells in macaques protected from SIV challenge by prior SIV subunit vaccination.

Mengovirus leader is involved in the inhibition of host cell protein synthesis.

Human immunodeficiency virus type 1 gp120 induces anergy in human peripheral blood lymphocytes by inducing interleukin-10 production.

Unintegrated bovine leukemia virus DNA: association with viral expression and disease.

Inactivation of murine leukemia virus by compounds that react with the zinc finger in the viral nucleocapsid protein.

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Identification and characterization of a hepatitis delta virus RNA transcriptional promoter.

Human immunodeficiency virus Type 1 nucleocapsid protein (NCp7) directs specific initiation of minus-strand DNA synthesis primed by human tRNA(Lys3) in vitro: studies of viral RNA molecules mutated in regions that flank the primer binding site.

Down-regulation of paramyxovirus hemagglutinin-neuraminidase glycoprotein surface expression by a mutant fusion protein containing a retention signal for the endoplasmic reticulum.

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Structural analysis of human immunodeficiency virus type 1 Gag protein interactions, using cysteine-specific reagents.

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Interaction between hepatitis C virus core protein and E1 envelope protein.

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Antisense oligonucleotide inhibition of hepatitis C virus gene expression in transformed hepatocytes.

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Characterization of the functional properties of env genes from long-term survivors of human immunodeficiency virus type 1 infection.

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Characterization of the functional properties of env genes from long-term survivors of human immunodeficiency virus type 1 infection.

Content Provider	PubMed Central
Author	Sheridan, K. E. Lai, C. Zhang, L. Ho, D. D. Connor, R. I.
Abstract	A small number of persons infected with human immunodeficiency virus type 1 (HIV-1) remain clinically and immunologically healthy for more than a decade after infection. Recent reports suggest that these individuals may be infected with an attenuated strain of HIV-1; however, a common genetic basis for viral attenuation has not been found in all cases. In the present study, we examined the functional properties of the HIV-1 env genes from six long-term survivors. env clones were generated by PCR amplification of proviral env sequences, followed by cloning of the amplified regions into expression vectors. Eight to ten clones from each subject were screened by transient transfection for expression of the envelope precursor glycoprotein, gp160. Those clones expressing gp160 were then cotransfected with an HIV-1 luciferase reporter vector, pNL4-3Env(-)LUC(+) and evaluated for their ability to mediate infection of phytohemagglutinin-activated peripheral blood mononuclear cells in single-cycle infectivity assays. Clones expressing gp160 were identified for all six long-term survivors, indicating the presence of proviral env genes with intact open reading frames. For two subjects, D and DH, the encoded envelope glycoproteins yielded high levels of luciferase activity when pseudotyped onto HIV-1 virions and tested in single-cycle infectivity assays. In contrast, envelope glycoproteins cloned from four other long-term survivors were poorly processed and failed to mediate infection. Sequencing of the gp120/41 cleavage site and conserved gp41 cysteine residues of these clones did not reveal any obvious mutations to explain the functional defects. The functional activity of env clones from long-term survivors D and DH was comparable to that seen with several primary HIV-1 env genes cloned from individuals with disease progression and AIDS. These results suggest that the long-term survival of subjects D and DH is not associated with overt functional defects in env; however, functional abnormalities in env may contribute to maintaining a long-term asymptomatic state in the other four cases we studied.
Starting Page	5306
File Format	PDF
ISSN	10985514
e-ISSN	10985514
Journal	Journal of Virology
Issue Number	8
Volume Number	70
Language	English
Publisher Date	1996-08-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Virology Immunology Microbiology Insect Science

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