NDLI: Reduced α-adrenoceptor responsiveness and enhanced baroreflex sensitivity in Cry-deficient mice lacking a biological clock

Content Provider	PubMed Central
Author	Masuki, Shizue Todo, Takeshi Nakano, Yasushi Okamura, Hitoshi Nose, Hiroshi
Copyright Year	2005
Abstract	To reveal the role of clock genes in generating the circadian rhythm of baroreflexes, we continuously measured mean arterial pressure and baroreflex sensitivity in free-moving normal wild-type mice, and in Cry-deficient mice which lack a circadian rhythm, in constant darkness for 24 h. In wild-type mice the mean arterial pressure was higher at night than during the day, and was accompanied by a significantly enhanced baroreflex sensitivity of −13.6 ± 0.8 at night compared with −9.7 ± 0.7 beats min−1 mmHg−1 during the day (P < 0.001). On the other hand, diurnal changes in arterial pressure disappeared in Cry-deficient mice with remarkably enhanced baroreflex sensitivity compared with wild-type mice (P < 0.001): −21.9 ± 1.6 at night and −23.1 ± 2.1 beats min−1 mmHg−1 during the day. Moreover, the mean arterial pressure response to 10 μg kg−1 of phenylephrine, an α1-adrenoceptor agonist, was severely suppressed in Cry-deficient mice regardless of time, while that for the wild-type mice was 10.1 ± 1.9 mmHg in the night, significantly lower than 22.0 ± 3.5 mmHg in the day (P < 0.01). These results suggest that CRY genes are involved in generating the circadian rhythm of baroreflex sensitivity, partially by regulating α1-adrenoceptor-mediated vasoconstriction in peripheral vessels.
Related Links	http://dx.doi.org/10.1113/jphysiol.2005.086728
Ending Page	224
Page Count	12
Starting Page	213
File Format	PDF
ISSN	00223751
e-ISSN	14697793
Journal	The Journal of Physiology
Issue Number	Pt 1
Volume Number	566
Language	English
Publisher	Blackwell Science Inc
Publisher Date	2005-07-01
Access Restriction	Open
Rights Holder	Blackwell Science Inc
Subject Keyword	Physiology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Physiology Sports Science

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