NDLI: Resetting of the arterial baroreflex increases orthostatic sympathetic activation and prevents postural hypotension in rabbits

Content Provider	PubMed Central
Author	Kamiya, Atsunori Kawada, Toru Yamamoto, Kenta Michikami, Daisaku Hideto, Ariumi Uemura, Kazunori Zheng, Can Shimizu, Syuji Aiba, Takeshi Miyamoto, Tadayoshi Sugimachi, Masaru Sunagawa, Kenji
Copyright Year	2005
Abstract	Since humans are under ceaseless orthostatic stress, the mechanism to maintain arterial pressure (AP) under orthostatic stress against gravitational fluid shift is of great importance. We hypothesized that (1) orthostatic stress resets the arterial baroreflex control of sympathetic nerve activity (SNA) to a higher SNA, and (2) resetting of the arterial baroreflex contributes to preventing postural hypotension. Renal SNA and AP were recorded in eight anaesthetized, vagotomized and aortic-denervated rabbits. Isolated intracarotid sinus pressure (CSP) was increased stepwise from 40 to 160 mmHg with increments of 20 mmHg (60 s for each CSP level) while the animal was placed supine and at 60 deg upright tilt. Upright tilt shifted the CSP–SNA relationship (the baroreflex neural arc) to a higher SNA, shifted the SNA–AP relationship (the baroreflex peripheral arc) to a lower AP, and consequently moved the operating point to marked high SNA while maintaining AP. A simulation study suggests that resetting in the neural arc would double the orthostatic activation of SNA and increase the operating AP in upright tilt by 10 mmHg, compared with the absence of resetting. In addition, upright tilt did not change the CSP–AP relationship (the baroreflex total arc). A simulation study suggests that although a downward shift of the peripheral arc could shift the total arc downward, resetting in the neural arc would compensate this fall and prevent the total arc from shifting downward to a lower AP. In conclusion, upright tilt increases SNA by resetting the baroreflex neural arc. This resetting may compensate for the reduced pressor responses to SNA in the peripheral cardiovascular system and contribute to preventing postural hypotension.
Related Links	http://dx.doi.org/10.1113/jphysiol.2005.086512
Ending Page	246
Page Count	10
Starting Page	237
File Format	PDF
ISSN	00223751
e-ISSN	14697793
Journal	The Journal of Physiology
Issue Number	Pt 1
Volume Number	566
Language	English
Publisher	Blackwell Science Inc
Publisher Date	2005-07-01
Access Restriction	Open
Rights Holder	Blackwell Science Inc
Subject Keyword	Physiology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Physiology Sports Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Mechanisms of sympathetic regulation in orthostatic intolerance.

Arterial baroreflex control of muscle sympathetic nerve activity under orthostatic stress in humans

Ventricular-Vascular Uncoupling in Heart Failure: Effects of Arterial Baroreflex-Induced Sympathoexcitation at Rest and During Exercise

Rapid resetting of human baroreflex working range: insights from sympathetic recordings during acute hypoglycaemia.

Modulation of arterial baroreflex dynamic response during mild orthostatic stress in humans

Increases in central blood volume modulate carotid baroreflex resetting during dynamic exercise in humans

Exercise-Induced Modulation of Baroreflex Control of Sympathetic Nerve Activity

Postural effects of vestibular-mediated sympathetic activation.

Insulin enhances the gain of arterial baroreflex control of muscle sympathetic nerve activity in humans

Resetting of the arterial baroreflex increases orthostatic sympathetic activation and prevents postural hypotension in rabbits

Similar Documents

Mechanisms of sympathetic regulation in orthostatic intolerance.

Arterial baroreflex control of muscle sympathetic nerve activity under orthostatic stress in humans

Ventricular-Vascular Uncoupling in Heart Failure: Effects of Arterial Baroreflex-Induced Sympathoexcitation at Rest and During Exercise

Rapid resetting of human baroreflex working range: insights from sympathetic recordings during acute hypoglycaemia.

Modulation of arterial baroreflex dynamic response during mild orthostatic stress in humans

Increases in central blood volume modulate carotid baroreflex resetting during dynamic exercise in humans

Exercise-Induced Modulation of Baroreflex Control of Sympathetic Nerve Activity

Postural effects of vestibular-mediated sympathetic activation.

Insulin enhances the gain of arterial baroreflex control of muscle sympathetic nerve activity in humans

Resetting of the arterial baroreflex increases orthostatic sympathetic activation and prevents postural hypotension in rabbits