NDLI: New Deoxyisoaustamide Derivatives from the Coral-Derived Fungus Penicillium dimorphosporum KMM 4689

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New Deoxyisoaustamide Derivatives from the Coral-Derived Fungus Penicillium dimorphosporum KMM 4689

Content Provider	MDPI
Author	Zhuravleva, Olesya Antonov, Alexandr Trang, Vo Pivkin, Mikhail Khudyakova, Yuliya Denisenko, Vladimir Popov, Roman Kim, Natalya Yurchenko, Ekaterina Gerasimenko, Andrey Udovenko, Anatoly Amsberg, Gunhild Dyshlovoy, Sergey Afiyatullov, Shamil
Copyright Year	2021
Description	Seven new deoxyisoaustamide derivatives (1–7) together with known compounds (8–10) were isolated from the coral-derived fungus Penicillium dimorphosporum KMM 4689. Their structures were established using spectroscopic methods, X-ray diffraction analysis and by comparison with related known compounds. The absolute configurations of some alkaloids were determined based on CD and NOESY data as well as biogenetic considerations. The cytotoxic and neuroprotective activities of some of the isolated compounds were examined and structure-activity relationships were pointed out. New deoxyisoaustamides 4–6 at concentration of 1 µM revealed a statistical increase of PQ(paraquat)-treated Neuro-2a cell viability by 30–39%.
Starting Page	32
e-ISSN	16603397
DOI	10.3390/md19010032
Journal	Marine drugs
Issue Number	1
Volume Number	19
Language	English
Publisher	MDPI
Publisher Date	2021-01-12
Access Restriction	Open
Subject Keyword	Marine drugs Marine Drugs Medicinal Chemistry Penicillium Dimorphosporum Secondary Metabolites Prenylated Indole Diketopiperazines Deoxyisoaustamide Neuroprotective Activity Paraquat
Content Type	Text
Resource Type	Article

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