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New Andrastin-Type Meroterpenoids from the Marine-Derived Fungus Penicillium sp.
| Content Provider | MDPI |
|---|---|
| Author | Ren, Jinwei Huo, Ruiyun Liu, Gaoran Liu, Ling |
| Copyright Year | 2021 |
| Description | Three new andrastin-type meroterpenoids penimeroterpenoids A–C (1–3) together with two known analogs (4 and 5) were isolated from the cultures of the marine-derived Penicillium species (sp.). The structures of the new compounds were elucidated on the basis of 1- and 2-dimensional (1D/2D) Nuclear Magnetic Resonance (NMR) spectroscopic and mass spectrometric analysis. The absolute configurations of 1–3 were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compound 1 showed moderate cytotoxicity against A549, HCT116, and SW480 cell lines. |
| Starting Page | 189 |
| e-ISSN | 16603397 |
| DOI | 10.3390/md19040189 |
| Journal | Marine drugs |
| Issue Number | 4 |
| Volume Number | 19 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-03-27 |
| Access Restriction | Open |
| Subject Keyword | Marine drugs Marine Drugs Medicinal Chemistry Organic Chemistry Marine-derived Fungus Secondary Metabolites Meroterpenoids Absolute Configurations Cytotoxicity |
| Content Type | Text |
| Resource Type | Article |