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New Diterpenoids and Isocoumarin Derivatives from the Mangrove-Derived Fungus Hypoxylon sp.
| Content Provider | MDPI |
|---|---|
| Author | Hou, Bolin Liu, Sushi Huo, Ruiyun Li, Yueqian Ren, Jinwei Wang, Wenzhao Wei, Tao Jiang, Xuejun Yin, Wenbing Liu, Hongwei Liu, Ling Li, Erwei |
| Copyright Year | 2021 |
| Description | Two new diterpenoids, hypoxyterpoids A (1) and B (2), and four new isocoumarin derivatives, hypoxymarins A–D (4–7), together, with seven known metabolites (3 and 8–13) were obtained from the crude extract of the mangrove-derived fungus Hypoxylon sp. The structures of the new compounds were elucidated on the basis of 1- and 2-dimensional (1D/2D) nuclear magnetic resonance (NMR) spectroscopic and mass spectrometric analysis. The absolute configurations of compounds 1, 2, 4, 5, and 7 were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra, and the absolute configurations of C-4′ in 6 and C-9 in 7 were determined by $[Rh_{2}(OCOCF_{3})_{4}$]-induced ECD spectra. Compound 1 showed moderate α-glucosidase inhibitory activities with $IC_{50}$ values of 741.5 ± 2.83 μM. Compounds 6 and 11 exhibited DPPH scavenging activities with $IC_{50}$ values of 15.36 ± 0.24 and 3.69 ± 0.07 μM, respectively. |
| Starting Page | 362 |
| e-ISSN | 16603397 |
| DOI | 10.3390/md19070362 |
| Journal | Marine drugs |
| Issue Number | 7 |
| Volume Number | 19 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-06-24 |
| Access Restriction | Open |
| Subject Keyword | Marine drugs Marine Drugs Medicinal Chemistry Mangrove-derived Fungus Secondary Metabolites Absolute Configurations Bioactivity |
| Content Type | Text |
| Resource Type | Article |
