NDLI: New Prenylated Indole Homodimeric and Pteridine Alkaloids from the Marine-Derived Fungus Aspergillus austroafricanus Y32-2

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New Prenylated Indole Homodimeric and Pteridine Alkaloids from the Marine-Derived Fungus Aspergillus austroafricanus Y32-2

Content Provider	MDPI
Author	Li, Peihai Zhang, Mengqi Li, Haonan Wang, Rongchun Hou, Hairong Li, Xiaobin Liu, Kechun Chen, Hao
Copyright Year	2021
Description	Chemical investigation of secondary metabolites from the marine-derived fungus Aspergillus austroafricanus Y32-2 resulted in the isolation of two new prenylated indole alkaloid homodimers, di-6-hydroxydeoxybrevianamide E (1) and dinotoamide J (2), one new pteridine alkaloid asperpteridinate A (3), with eleven known compounds (4–14). Their structures were elucidated by various spectroscopic methods including HRESIMS and NMR, while their absolute configurations were determined by ECD calculations. Each compound was evaluated for pro-angiogenic, anti-inflammatory effects in zebrafish models and cytotoxicity for HepG2 human liver carcinoma cells. As a result, compounds 2, 4, 5, 7, 10 exhibited pro-angiogenic activity in a PTK787-induced vascular injury zebrafish model in a dose-dependent manner, compounds 7, 8, 10, 11 displayed anti-inflammatory activity in a CuSO4-induced zebrafish inflammation model, and compound 6 showed significant cytotoxicity against HepG2 cells with an IC50 value of 30 µg/mL.
Starting Page	98
e-ISSN	16603397
DOI	10.3390/md19020098
Journal	Marine drugs
Issue Number	2
Volume Number	19
Language	English
Publisher	MDPI
Publisher Date	2021-02-09
Access Restriction	Open
Subject Keyword	Marine drugs Marine Drugs Medicinal Chemistry Marine-derived Fungus Aspergillus Austroafricanus Novel Bioactive Metabolites Pro-angiogenesis Anti-inflammatory Effects
Content Type	Text
Resource Type	Article

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