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Hemiacetalmeroterpenoids A–C and Astellolide Q with Antimicrobial Activity from the Marine-Derived Fungus Penicillium sp. N-5
| Content Provider | MDPI |
|---|---|
| Author | Chen, Tao Yang, Wencong Li, Taobo Yin, Yihao Liu, Yufeng Wang, Bo She, Zhigang |
| Copyright Year | 2022 |
| Description | Four new compounds including three andrastin-type meroterpenoids hemiacetalmeroterpenoids A-C (1–3), and a drimane sesquiterpenoid astellolide Q (15), together with eleven known compounds (4–14) were isolated from the cultures of the marine-derived fungus Penicillium sp. N-5, while compound 14 was first isolated from a natural source. The structures of the new compounds were determined by analysis of detailed spectroscopic data, and the absolute configurations were further decided by a comparison of the experimental and calculated ECD spectra. Hemiacetalmeroterpenoid A (1) possesses a unique and highly congested 6,6,6,6,5,5-hexa-cyclic skeleton. Moreover, the absolute configuration of compound 14 was also reported for the first time. Compounds 1, 5 and 10 exhibited significant antimicrobial activities against Penicillium italicum and Colletrichum gloeosporioides with MIC values ranging from 1.56 to 6.25 μg/mL. |
| Starting Page | 514 |
| e-ISSN | 16603397 |
| DOI | 10.3390/md20080514 |
| Journal | Marine drugs |
| Issue Number | 8 |
| Volume Number | 20 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-08-13 |
| Access Restriction | Open |
| Subject Keyword | Marine drugs Marine Drugs Toxicology Andrastin-type Meroterpenoids Drimane Sesquiterpenoid Marine-derived Fungus Antimicrobials Activities |
| Content Type | Text |
| Resource Type | Article |
