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| Content Provider | IET Digital Library |
|---|---|
| Author | Ye, Yifei Zhao, Yang Cheng, Jie Li, Mingxiao Huang, Chengjun |
| Abstract | Capillary-driven microfluidic devices have a great potential for the point-of-care testing systems based on the advantages of self-pumping, low reagent usage and rapid detection. Here, the study presents a lidless Si-based capillary-driven microfluidic device, comprising two inlets for sample and buffer loading, a snake-shaped microchannel (120/0.05/0.025 mm in length/width/depth) as a flow resistor, a micropillar array (25/5/8 μm in height/diameter/pitch) as a capillary pump and a vent. It was fabricated with lithographic technique in combination with deep Si etch technique. A simple and stable surface hydrophilisation modification method was demonstrated on the device by forming a self-assembly monolayer through Cu-catalysed azide-alkyne cycloaddition reaction. The surface modified device allowed controllable autonomous capillary flow delivery with a contact angle of around 40° stabilised for at least 90 days. The design of two inlets with one common long snake-shaped microchannel provided the sequential capillary flow generation and propagation with controlled flow rate and propagation distance, while the micropillar array with a high aspect ratio of 5 was considered as an effective capillary pump. Based on the obtained results, the proposed device makes possible for the on-chip biosensing applications as a part of integrated point-of-care testing systems. |
| Starting Page | 1682 |
| Ending Page | 1687 |
| Page Count | 6 |
| Volume Number | 13 |
| e-ISSN | 17500443 |
| Issue Number | Issue 12, Dec (2018) |
| Alternate Webpage(s) | https://digital-library.theiet.org/content/journals/mnl/13/12 |
| Alternate Webpage(s) | https://digital-library.theiet.org/content/journals/10.1049/mnl.2018.5120 |
| Journal | Micro & Nano Letters |
| Publisher Date | 2018-12-01 |
| Access Restriction | Open |
| Rights Holder | © The Institution of Engineering and Technology |
| Subject Keyword | Aspect Ratio Buffer Loading Capillarity Catalysis Contact Angle Controllable Autonomous Capillary Flow Delivery Controlled Flow Rate Copper Copper-catalysed Azide-alkyne Cycloaddition Reaction Deep Silicon Etch Technique Depth 0.025 Mm Design And Modelling of MEMS And NEMS Device Effective Capillary Pump Elemental Semiconductor Etching Fabrication of MEMS And NEMS Device Flow Resistor Hydrophobicity Lidless Silicon-based Capillary-driven Microfluidic Device Lithographic Technique Lithography Microfabrication Microfluidics Micropillar Array MonoLayer Photolithography Point-of-care Testing System Propagation Distance Self-assembly Self-assembly Monolayer Self-pumping Semiconductor Technology Sequential Capillary Flow Generation Silicon Size 0.05 Mm Size 120.0 Mm Size 25.0 Mum Size 5.0 Mum Snake-shaped Microchannel Surface Hydrophilisation Modification Method Surface Modified Device Surface Topography Measurement |
| Content Type | Text |
| Resource Type | Article |
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