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| Content Provider | IET Digital Library |
|---|---|
| Author | Bhattacharjee, Sukanta Banerjee, Ansuman Bhattacharya, Bhargab B. |
| Abstract | Digital microfluidic (DMF) biochips offer a versatile platform for implementing several laboratory based biochemical protocols. These tiny chips can electrically control the dynamics of nanoliter volume of discrete fluid droplets on an electrode array by application of actuation patterns. One important step in biochemical sample preparation is dilution, where the objective is to prepare a fluid with a desired concentration factor. The protocols implemented on DMF biochips may require several different concentration values of a sample. In this study, the authors propose a scheme to produce such target droplets from a supply of an input sample and a buffer solution. Simulation results show a significant amount of savings in the number of mix-split steps and waste droplets in comparison to other methods for generating multiple concentration factors. |
| Starting Page | 49 |
| Ending Page | 58 |
| Page Count | 10 |
| ISSN | 17518601 |
| Volume Number | 8 |
| e-ISSN | 1751861X |
| Issue Number | Issue 1, Jan (2014) |
| Alternate Webpage(s) | https://digital-library.theiet.org/content/journals/iet-cdt/8/1 |
| Alternate Webpage(s) | https://digital-library.theiet.org/content/journals/10.1049/iet-cdt.2013.0053 |
| Journal | IET Computers & Digital Techniques |
| Access Restriction | Open |
| Rights Holder | © The Institution of Engineering and Technology |
| Subject Keyword | Actuation Pattern Applied Fluid Mechanics Biochemical Sample Preparation Biochemistry Biophysical Instrumentation And Technique Buffer Solution Concentration Factor Digital Microfluidic Biochips Dilution Discrete Fluid Droplet Dynamics DMF Biochips Drops Electrode Array Electrohydrodynamics Flow Control Lab-on-a-chip Laboratory Based Biochemical Protocol Level, Flow And Volume Control Magnetohydrodynamics And Electrohydrodynamics Microfluidics Mix-split Steps Multiphase Flows Waste Droplets |
| Content Type | Text |
| Resource Type | Article |
| Subject | Electrical and Electronic Engineering Hardware and Architecture Software |
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