NDLI: Fluid-level synthesis unifying reliability, contamination avoidance, and capacity-wastage-aware washing for droplet-based microfluidic biochips

Content Provider	IET Digital Library
Author	Chakraborty, Arpan Datta, Piyali Pal, Rajat Kumar
Abstract	Production of correct bioassay outcome is the foremost objective in digital microfluidic biochips (or DMFBs). In high-frequency DMFBs, continuous actuation of electrodes leads to malfunctioning or even breakdown of the system. The improper functioning of a biochip tends to produce erroneous results. On the other hand, while transporting droplets, the residues may get stuck to electrode walls and cause contamination to other droplets. To ensure proper assay outcome, washing becomes mandatory, whose incorporation may delay the bioassay completion time significantly. Furthermore, each wash droplet possesses a capacity constraint within which the residues can be washed off successfully. Evidently, the design objectives possess a large degree of trade-offs among themselves and must be attacked to prepare an efficient platform. Here, the authors propose a complete fluid-level synthesis considering all the essential goals together instead of dealing with them in isolation. The presented approach effectively handles the trade-off scenarios and provides flexibility to the designer to decide the threshold of the individual optimisation objective leading to the construction of a good-quality solution as a whole. The performance is evaluated over several benchmark bioassays.
Starting Page	166
Ending Page	177
Page Count	12
ISSN	17518601
Volume Number	13
e-ISSN	1751861X
Issue Number	Issue 3, May (2019)
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/iet-cdt/13/3
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/10.1049/iet-cdt.2018.5037
Journal	IET Computers & Digital Techniques
Publisher Date	2018-09-05
Access Restriction	Open
Rights Holder	© The Institution of Engineering and Technology
Subject Keyword	Benchmark Bioassays Bioassay Completion Time Biochip Biological Technique BioMEMS Biophysical Instrumentation And Technique Capacity Constraint Capacity-wastage-aware Washing Complete Fluid-level Synthesis Contamination Avoidance Correct Bioassay Outcome Design Objectives Digital Microfluidic Biochips Droplet-based Microfluidic Biochips Drops Electrode Walls High-frequency DMFBs Lab-on-a-chip MEMS And NEMS Device Technology Microfluidics Micromechanical And Nanomechanical Device And System Optimisation Optimisation Objective Optimisation Technique
Content Type	Text
Resource Type	Article
Subject	Electrical and Electronic Engineering Hardware and Architecture Software

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