NDLI: PI controller based closed loop drug delivery for the long term blood pressure regulation

Content Provider	IEEE Xplore Digital Library
Author	Shahin, M. Maka, S.
Copyright Year	2012
Description	Author affiliation: Department of Electrical and Electronics Engineering, Government College of Engineering Kannur, Kerala, India (Shahin, M.) \|\| Department of Electrical Engineering, Indian Institute of Technology Kharagpur, WB, India (Maka, S.)
Abstract	Mean arterial pressure (MAP) is a key variable to decide the performance and operating point of cardiovascular system (CVS) and its maintenance is of vital importance for the human body. This paper focuses on an automatic system to provide closed loop control of MAP. A proportional plus integral controller is proposed for long term arterial blood pressure regulation. This controller is designed so that the actual MAP stays within a narrow range of pressure even under dynamic variations in aldosterone hormone levels. Based on the pressure level change under aldosterone loading, the PI controller administrates sodium infusion and the validity is tested for a seventh order blood pressure regulation model. Simulation results indicate that the controller is capable of avoiding the offset and oscillatory behavior during transients. The settling time is also within acceptable limits. The automated drug delivery is seen to be effective and superior to manual control of ABP regulation. The study presented here opens a potentially viable approach to the design of safer automatic closed loop drug administration technology for the long term blood pressure control.
Starting Page	998
Ending Page	1002
File Size	675260
Page Count	5
File Format	PDF
ISBN	9781467322706
e-ISBN	9781467322720
DOI	10.1109/INDCON.2012.6420762
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-12-07
Publisher Place	India
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Drugs blood pressure cardiovascular system state model Arterial blood pressure aldosterone nonlinear model Control systems sodium infusion Loading Blood pressure Physiology Mathematical model hypertension
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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