NDLI: Biocompatibility evaluation of parylene C and polyimide as substrates for peripheral nerve interfaces

Content Provider	IEEE Xplore Digital Library
Author	del Valle, J. de la Oliva, N. Muller, M. Stieglitz, T. Navarro, X.
Copyright Year	2015
Description	Author affiliation: Dept. of Cell Biol., Physiol. & Immunology, Univ. Autonoma de Barcelona, Bellaterra, Spain (del Valle, J.; de la Oliva, N.; Navarro, X.) \|\| Dept. of Microsyst. Eng. (IMTEK), Univ. of Freiburg, Freiburg, Germany (Muller, M.; Stieglitz, T.)
Abstract	For assessing the suitability of a given material for peripheral nerve implantation, acute and chronic tests to investigate tissue reaction, and evaluate the thickness of fibroblast layers that surround the material and the presence of inflammatory cells are mandatory. In this study we compared in vivo the biocompatibility of parylene C and polyimide, two materials intended for fabrication of neural electrodes. We have tested these two materials after implantation of thin devices in the peripheral nerve of rats, by functional and morphological methods, assessing thickness of the fibrotic capsule, signs of inflammation and axon survival in areas close to the implant. Intraneural implantation of parylene C and polyimide devices did not produce any functional alteration in the sciatic nerve, as evidenced by electrophysiological, locomotion and nociceptive functional tests. The intraneural devices were encapsulated within a fibroblastic tissue. Resolution of the inflammatory infiltrate took 4-8 weeks. In conclusion, both parylene and polyimide electrodes show biocompatible characteristics and induce a similar fibrotic reaction after chronic intraneural implantation.
Starting Page	442
Ending Page	445
File Size	885892
Page Count	4
File Format	PDF
ISBN	9781467363891
DOI	10.1109/NER.2015.7146654
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-04-22
Publisher Place	France
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Electrodes Nerve fibers Surgery Implants Polyimides Rats
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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