NDLI: Influence of encapsulation tissue reaction on the volume of tissue activated with deep-brain stimulation electrodes: A simulation study

Content Provider	IEEE Xplore Digital Library
Author	Djilas, M. Mercanzini, A. Harbi, P. Dransart, A. Jezernik, S.
Copyright Year	2015
Description	Author affiliation: Altran Switzerland, Switzerland (Djilas, M.; Jezernik, S.) \|\| Aleva Neurotherapeutics, Lausanne, Switzerland (Mercanzini, A.; Harbi, P.; Dransart, A.)
Abstract	The goal of this study was to determine the influence of tissue reaction on the volume of brain tissue that can be activated using implanted directional deep brain stimulation microelectrodes. A finite-element method model of an electrode structure and its interface with the surrounding neural tissue was developed. Electrical and geometrical parameters of the fibrous tissue encapsulation were varied in the model to determine their impact on the volume of activated brain tissue surrounding the microelectrodes. Results: both the electrical conductivity change (from short- to long-term implantation reference values) and the increase of encapsulation thickness were shown to have a significant influence on the reduction of the volume of the activated tissue. The thickness parameter was shown to be a dominant factor.
Starting Page	284
Ending Page	287
File Size	719419
Page Count	4
File Format	PDF
ISBN	9781467363891
DOI	10.1109/NER.2015.7146615
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-04-22
Publisher Place	France
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Electrodes Encapsulation Conductivity Lead Brain modeling Brain stimulation
Content Type	Text
Resource Type	Article

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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