NDLI: Photovoltaic restoration of high visual acuity in rats with retinal degeneration

Content Provider	IEEE Xplore Digital Library
Author	Lorach, H. Goetz, G. Mandel, Y. Smith, R. Boinagrov, D. Lei, X. Dalal, R. Huie, P. Kamins, T. Harris, J. Mathieson, K. Sher, A. Palanker, D.
Copyright Year	2015
Description	Author affiliation: Inst. of Photonics, Univ. of Strathclyde, Glasgow, UK (Mathieson, K.) \|\| Santa Cruz Inst. for Particle Phys., Univ. of California, CA, USA (Smith, R.; Sher, A.) \|\| Dept. of Electr. Eng., Stanford Univ., Stanford, CA, USA (Lei, X.; Kamins, T.; Harris, J.) \|\| Dept. of Ophthalmology, Stanford Univ., Stanford, CA, USA (Dalal, R.; Huie, P.) \|\| Hansen Exp. Phys. Lab., Stanford Univ., Stanford, CA, USA (Lorach, H.; Goetz, G.; Mandel, Y.; Boinagrov, D.; Palanker, D.)
Abstract	Patients with retinal degeneration lose sight due to gradual demise of photoreceptors. Electrical stimulation of the surviving retinal neurons provides an alternative route for delivery of visual information. We developed subretinal photovoltaic arrays to convert pulsed light into bi-phasic pulses of current to stimulate the nearby inner retinal neurons. Bright pulsed illumination is provided by image projection from video goggles and avoids photophobic effects by using near-infrared (NIR, 880-915nm) light. Experiments in-vitro and in-vivo demonstrate that the network-mediated retinal stimulation preserves many features of natural vision, such as flicker fusion, adaptation to static images, and most importantly, high spatial resolution. Our implants with 70μm pixels restored visual acuity to half of the normal level in rats with retinal degeneration. Ease of implantation and tiling of these wireless arrays to cover a large visual field, combined with their high resolution opens the door to highly functional restoration of sight.
Starting Page	248
Ending Page	251
File Size	1895803
Page Count	4
File Format	PDF
ISBN	9781467363891
DOI	10.1109/NER.2015.7146606
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-04-22
Publisher Place	France
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Photovoltaic systems Visualization Implants Retina Gratings Prosthetics
Content Type	Text
Resource Type	Article

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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