NDLI: Deep Brain Stimulation for Obesity Control: Analyzing Stimulation Parameters to Modulate Energy Expenditure

Content Provider	IEEE Xplore Digital Library
Author	Covalin, A. Feshali, A. Judy, J.
Copyright Year	2005
Description	Author affiliation: Biomed. Eng. Interdepartamental Program, California Univ., Los Angeles, CA (Covalin, A.)
Abstract	Obesity, with 300,000 deaths and a $75 billion economic burden per year is the second leading cause of death after tobacco in the United States. Obesity arises from an imbalance in the energy homeostasis system. Among several hypothalamic regions that control this homeostatic system, the ventrolmedial hypothalamic nucleus (VMH) stands out as a target for the development of a new clinical application in which deep brain stimulation (DBS) could be used to treat obesity. We have assembled a system capable of following in real-time the resting energy expenditure (REE) in response to DBS in the VMH. In this manuscript, we discuss a preliminary analysis of the DBS parameters needed to efficiently modulate energy expenditure. Our findings show that DBS in the VMH can increases the REE without affecting the mechanical energy expenditure (MEE) in a manner that appears to be frequency dependent. Our overall objective is to analyze the stimulation parameters of DBS in the VMH so that the feasibility of a clinical application for morbid obesity can be assessed
Starting Page	482
Ending Page	485
File Size	2064779
Page Count	4
File Format	PDF
ISBN	0780387104
DOI	10.1109/CNE.2005.1419665
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2005-03-16
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Satellite broadcasting Surgery Cardiac disease Psychology Power generation economics Control systems Mechanical energy Brain stimulation Lesions Modulation coding
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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