NDLI: The effect of nucleoside anticancer drugs on the development of mouse embryos

Content Provider	IEEE Xplore Digital Library
Author	Xiu-Li Chen Li-Bing Ma
Copyright Year	2011
Description	Author affiliation: School of Mathematics Physics and Biological Engineering, Inner Mongolia University of Science and Technology, Baotou, China (Xiu-Li Chen; Li-Bing Ma)
Abstract	The purpose of this study was to investigate the effect of two nucleoside anticancer drugs, 5-fluorouracil (5-FU) and 5-azacitidine (5-aza), on the development of mouse embryos. The study was performed as described following: (a) mouse embryos were culture in CZB medium supplemented with 5-FU or 5-aza; (b) mouse embryos derived from 5-FU or 5-aza treated mice were cultured in CZB medium. The developmental ability of mouse embryos cultured in vitro was used to assess the effect of two drugs on the development of mouse embryos. (c) female mice were treated with 5-FU, the rate of abnormal neonatal mice was used to assess the teratogenicity of 5-FU. The results showed that both drugs could prevent mouse embryos developing in vitro; moreover, most of embryos derived from 5-FU treated mice lost developmental ability, but few of these embryos could still develop to term, and neonatal mice did not exhibited abnormal phenotype.
Starting Page	722
Ending Page	725
File Size	115866
Page Count	4
File Format	PDF
ISBN	9781612847016
e-ISBN	9781612847047
DOI	10.1109/ITiME.2011.6130761
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-12-09
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Drugs 5-fluorouracil Pediatrics mouse Embryo embryos DNA Educational institutions Mice 5-azacitidine In vitro
Content Type	Text
Resource Type	Article

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