NDLI: Design and Analysis of a High Sensitive Microcantilever Biosensor for Biomedical Applications

Content Provider	IEEE Xplore Digital Library
Author	Ansari, M.Z. Chongdu Cho
Copyright Year	2008
Description	Author affiliation: Dept. of Mech. Eng., Inha Univ., Incheon (Ansari, M.Z.; Chongdu Cho)
Abstract	Although becoming popular in label-free, rapid, and real-time assaying of biomolecules, the sensitivity of microcantilever biosensors decrease as the concentration of analytes decrease. The sensitivity of a microcantilever biosensor depends on its deflection that occurs due to interaction between the analyte and its bioreceptor molecule. Therefore, designing a cantilever biosensor which can assay analytes in low concentrations is important. In this study, we propose a new cantilever design that can detect and measure analytes in extremely low concentrations. By introducing a narrow strip towards the fixed end of the rectangular cantilever, we can reduce cantilever flexural stiffness and hence increase the deflections at its free end. A commercial finite element analysis software ANSYS is used to analyze and verify the proposed model. Results show the proposed cantilever bends nearly twice the conventional for same surface stress. This high sensitive design can significantly increase the sensitivity and range of cantilever biosensors. Furthermore, using a combination of conventional and proposed cantilevers array on same chip, a universal microcantilever biosensor can be designed that can assay analytes in large dynamic concentration range.
Starting Page	593
Ending Page	597
File Size	434282
Page Count	5
File Format	PDF
ISBN	9780769531182
DOI	10.1109/BMEI.2008.308
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-05-27
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Transducers Scalability Entropy Stress Proteins Stony equation Sensitivity DNA Biosensor Molecular biophysics Microcantilever Biomarkers Biosensors Labeling Label-free
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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