NDLI: Absolute Quantification of Swine Brain Glutamate Compounds Concentration using MR Spectroscopy and LCModel after Nasal Spraying Butorphanol Tartrate

Content Provider	IEEE Xplore Digital Library
Author	Wu, J.L. Liu, T. Lin, Y. Shen, Z.W. Miao, Y.W. Wu, R.H. Lang, Z.J.
Copyright Year	2008
Description	Author affiliation: Dept. of Med. Imaging, DaLian Med. Univ., Dalian (Wu, J.L.; Liu, T.)
Abstract	The purpose of this study was to investigate whether the Central Nervous System (CNS) analgesics affect the metabolites of swine brain by nasal spraying. Single voxel proton magnetic resonance spectroscopy $(^{1}H-MRS)$ was performed on 9 swine. The data were post-processed using LCModel software. Before nasal spraying butorphanol tartrate, the mean Glutamate compounds (Glx) concentration was 9.276+0.542 mmol/kg. After nasal spraying, the mean Glx concentration was 7.283plusmn0.540 mmol/kg. Using paired sample t-test we found that swine brain Glx level was significantly decreased after using nasal spray analgesic (t=2.826, p=0.022). However, there were no significant differences concerning mean NAA concentrations and mean Choline (Cho) concentrations before and after nasal spraying. Before nasal spraying, the mean NAA and Cho concentrations were 6.094+0.384 mmol/kg and 1.547+0.114 mmol/kg, respectively. After nasal spraying, the mean NAA and Cho concentrations were 5.530+0.346 mmol/kg and 1.255+0.079 mmol/kg, respectively. Our results imply that Glx are nociceptive neurotransmitters and play an important role in the analgesia.
Starting Page	348
Ending Page	352
File Size	808064
Page Count	5
File Format	PDF
ISBN	9780769531182
DOI	10.1109/BMEI.2008.96
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-05-27
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Drugs Protons Spectroscopy In vivo Neurotransmitters Hospitals Spraying Magnetic resonance Central nervous system Biomedical imaging
Content Type	Text
Resource Type	Article

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