NDLI: Survival of Rats with N29 Brain Tumours after Irradiation with 5 or 15 Gy and Immunization with IFN-gamma Secreting Tumour Cells

Content Provider	IEEE Xplore Digital Library
Author	Persson, B.R.R. Koch, C.B. Grafstrom, G. Ceberg, C. Rosenschold, P.M. Widegren, B. Salford, L.G.
Copyright Year	2008
Description	Author affiliation: Dept. Radiat. Phys., Lund Univ., Lund (Persson, B.R.R.)
Abstract	Intra cerebral tumours were inoculated into the brain of Fischer-344 syngeneic rats. After one week they were treated with either 5 or 15 Gy of $^{60}Co-gamma$ radiation. The first immunization was given 1 hour before the radiation treatment and then two more times with 14-day intervals. Immunization was performed with 3 times $10^{6}$ radiation sterilized IFN-gamma secreting tumour cells (N29) injected intraperitoneally. Neither radiation therapy with 5 or 15 Gy nor immunization with N29 cells alone had any significant effect on the length of survival of N29 tumour bearing rats. But radiation therapy with 5 Gy combined with immunization with IFN-gamma secreting syngeneic N29 cells resulted in 63 % complete remissions and significantly (p < 0.05) increased survival for the tumour bearing rats. Corresponding combination with 15 Gy RT resulted in 50% complete remissions. There is a possibility of a synergistic effect by optimal combination of radiation therapy and immunization.
Starting Page	243
Ending Page	247
File Size	257887
Page Count	5
File Format	PDF
ISBN	9780769531182
DOI	10.1109/BMEI.2008.345
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-05-27
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Brain tumour Medical treatment Humans Biomedical informatics Rats Physics Animals IFN-gamma Biomedical applications of radiation Immuno therapy Radio therapy Tumors Immune system Biomedical engineering
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

“Abscopal” Effect of Radiation Therapy Combined with Immune-Therapy Using IFN-γ Gene Transfected Syngeneic Tumor Cells, in Rats with Bilateral Implanted N29 Tumors

Pre-irradiation chemotherapy and hyperfractionated radiation therapy 66 Gy for children with brain stem tumors. A phase II study of the pediatric oncology group, protocol 8833

Response of intra- and extra-cerebral N29 gliomas in rats to the combination of radiation therapy and immunization

Hyperfractionated radiation therapy (72 Gy) for children with brain stem gliomas A childrens cancer group phase I/II trial

Hepatic irradiation in the management of metastatic hormone-secreting tumors

214 studies on the induction of bone and soft tissue tumours in rats by gamma irradiation and the efect of growth hormone and thyroxine (1959).

Rats with Intracerebral Tumors ofMercaptoethylguanidine Prolongs Survival Nitric Oxide Synthase Inhibitor Glioma Cells Combined with the Inducible-Secreting γ Postimmunization with IFN-Smith

Melioidosis Patient Survival Correlates With Strong IFN-γ Secreting T Cell Responses Against Hcp1 and TssM

Biomedical and environmental research program of the LASL Health Division. Annual report, January--December 1974

Survival of Rats with N29 Brain Tumours after Irradiation with 5 or 15 Gy and Immunization with IFN-gamma Secreting Tumour Cells

Similar Documents

“Abscopal” Effect of Radiation Therapy Combined with Immune-Therapy Using IFN-γ Gene Transfected Syngeneic Tumor Cells, in Rats with Bilateral Implanted N29 Tumors

Pre-irradiation chemotherapy and hyperfractionated radiation therapy 66 Gy for children with brain stem tumors. A phase II study of the pediatric oncology group, protocol 8833

Response of intra- and extra-cerebral N29 gliomas in rats to the combination of radiation therapy and immunization

Hyperfractionated radiation therapy (72 Gy) for children with brain stem gliomas A childrens cancer group phase I/II trial

Hepatic irradiation in the management of metastatic hormone-secreting tumors

214 studies on the induction of bone and soft tissue tumours in rats by gamma irradiation and the efect of growth hormone and thyroxine (1959).

Rats with Intracerebral Tumors ofMercaptoethylguanidine Prolongs Survival Nitric Oxide Synthase Inhibitor Glioma Cells Combined with the Inducible-Secreting γ Postimmunization with IFN-Smith

Melioidosis Patient Survival Correlates With Strong IFN-γ Secreting T Cell Responses Against Hcp1 and TssM

Biomedical and environmental research program of the LASL Health Division. Annual report, January--December 1974

Survival of Rats with N29 Brain Tumours after Irradiation with 5 or 15 Gy and Immunization with IFN-gamma Secreting Tumour Cells