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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Xue-juan Li Mishra, S.K. Min Wu Fan Zhang Jie Zheng |
| Copyright Year | 2013 |
| Description | Author affiliation: Inst. for Infocomm Res., Singapore, Singapore (Min Wu) || Bioinf. Res. Centre, Technol. Univ., Singapore, Singapore (Xue-juan Li; Mishra, S.K.; Fan Zhang; Jie Zheng) |
| Abstract | Synthetic lethality (SL) is a novel strategy for anticancer therapies, whereby mutations of two genes will kill a cell but mutation of a single gene will not. Therefore, a cancer-specific mutation combined with a drug-induced mutation, if they have SL interactions, will selectively kill cancer cells. While numerous SL interactions have been identified in yeast, only a few have been known in human. There is a pressing need to systematically discover and understand SL interactions specific to human cancer. In this paper, we present Syn-Lethality, the first integrative knowledge base of SL that is dedicated to human cancer. It integrates experimentally discovered and verified human SL gene pairs into a network, associated with annotations of gene functions, pathways and molecular mechanisms. It also includes yeast SL genes from high-throughput screenings which are mapped to orthologous human genes. Such an integrative knowledge base, organized as a relational database with user interface for searching and network visualization, will greatly expedite the discovery of novel anticancer drug targets based on synthetic lethality interactions. |
| Sponsorship | IEEE Comput.Soc. |
| Starting Page | 4 |
| Ending Page | 4 |
| File Size | 104674 |
| Page Count | 1 |
| File Format | |
| ISBN | 9781479913091 |
| DOI | 10.1109/BIBM.2013.6732609 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2013-12-18 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Computers Knowledge based systems Medical treatment Pressing Educational institutions Electronic mail Cancer |
| Content Type | Text |
| Resource Type | Article |
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