Please wait, while we are loading the content...
| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Jiangwen Sun Jinbo Bi Kranzler, H.R. |
| Copyright Year | 2013 |
| Description | Author affiliation: Dept. of Comput. Sci. & Eng., Univ. of Connecticut, Storrs, CT, USA (Jiangwen Sun; Jinbo Bi) || Treatment Res. Center, Univ. of Pennsylvania, Philadelphia, PA, USA (Kranzler, H.R.) |
| Abstract | Complex disorders exhibit great heterogeneity in both clinical manifestation and genetic etiology. This heterogeneity substantially limits the identification of geneotype-phenotype associations. Differentiating homogeneous subtypes of a complex phenotype will enable the detection of genetic variants contributing to the effect of subtypes that cannot be detected by the non-differentiated phenotype. However, the most sophisticated subtyping methods available so far perform unsupervised cluster analysis or latent class analysis on only phenotypic features. Without guidance from the genetic dimension, the resultant subtypes can be suboptimal and genetic associations may fail. We propose a multi-view biclustering approach that integrates phenotypic features and genetic markers to detect confirming evidence in the two views for a disease subtype. This approach groups subjects in clusters that are consistent between the phenotypic and genetic views, and simultaneously identifies the phenotypic features that are used to define a subtype and the genotypes that are associated with the subtype. Our simulation study validates this approach, and our extensive comparison with several biclustering and multi-view data analytics on real-life disease data demonstrates the superior performance of the proposed approach. |
| Sponsorship | IEEE Comput.Soc. |
| Starting Page | 316 |
| Ending Page | 321 |
| File Size | 295271 |
| Page Count | 6 |
| File Format | |
| ISBN | 9781479913091 |
| DOI | 10.1109/BIBM.2013.6732509 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2013-12-18 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | genotype-phenotype association Sociology Genetics Educational institutions multi-view data analysis Vectors Statistics Kernel biclustering subtyping Diseases substance dependence |
| Content Type | Text |
| Resource Type | Article |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|