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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Pathak, J. Kiefer, R.C. Chute, C.G. |
| Copyright Year | 2013 |
| Description | Author affiliation: Dept. of Health Sci. Res., Mayo Clinic, Rochester, MN, USA (Pathak, J.; Kiefer, R.C.; Chute, C.G.) |
| Abstract | By nature, healthcare data is highly complex and voluminous. While on one hand, it provides unprecedented opportunities to identify hidden and unknown relationships between patients and treatment outcomes, or drugs and allergic reactions for given individuals, representing and querying large network datasets poses significant technical challenges. In this research, we study the use of Semantic Web and Linked Data technologies for identifying potential drug-drug interaction (DDI) information from publicly available resources, and determining if such interactions were observed using real patient data. Specifically, we apply Linked Data principles and technologies for representing patient data from electronic health records (EHRs) at Mayo Clinic as Resource Description Framework (RDF) graphs, and identify potential DDIs for three widely prescribed cardiovascular drugs: Warfarin, Clopidogrel and Simvastatin. Our results from the proof-of-concept study demonstrate the potential of applying such a methodology to study patient health outcomes as well as enabling genome-guided drug therapies and treatment interventions. |
| Sponsorship | IEEE Comput.Soc. |
| Starting Page | 23 |
| Ending Page | 30 |
| File Size | 1336375 |
| Page Count | 8 |
| File Format | |
| ISBN | 9781479913091 |
| DOI | 10.1109/BIBM.2013.6732595 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2013-12-18 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Drugs Semantic Web Electric potential Linked Data Ontologies Resource description framework Electronic medical records Medical diagnostic imaging Drug-Drug Interaction |
| Content Type | Text |
| Resource Type | Article |
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