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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Duryea, A.P. Roberts, W.W. Cain, C.A. Hall, T.L. |
| Copyright Year | 2010 |
| Description | Author affiliation: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 (Duryea, A.P.; Roberts, W.W.; Cain, C.A.; Hall, T.L.) |
| Abstract | Previous work has demonstrated that histotripsy can effectively comminute model kidney stones, eroding them to sub-100 µm particulate debris via a cavitational bubble cloud. We now focus on optimization of the histotripsy parameter space and treatment strategies to yield optimal stone erosion. Ultracal-30 model stones were sonicated using a 750 kHz piezocomposite transducer. Pulses of 5 cycles in duration delivered at pulse repetition frequencies (PRFs) of 10 Hz, 100 Hz, and 1 kHz were tested. For each PRF, the erosion characteristics were investigated at increasing intensity levels corresponding to peak negative pressures (p-) of 10, 15, 19, 22, and 26 MPa. Additionally, the effect of exposed stone surface area was explored through the treatment of the same model stones that were first mechanically sectioned into 1/8's. Results show the following: (1) At PRF of 10 Hz, stone erosion rate was observed to increase linearly with p-; at 100 Hz and 1 kHz, erosion rate saturation was observed. (2) Increasing the PRF at a given intensity resulted in an increase in stone erosion; however, a 10fold increase in PRF did not produce an equivalent 10-fold increase in erosion rate. (3) Treatment of model stones sectioned into 1/8's produced a 2-fold rate increase relative to their unsectioned counterparts. (4) The maximum observed histotripsy stone treatment rate (88 mg/min) rivals that previously measured for a piezoelectric lithotripter (111 mg/min); this fact, coupled with histotripsy being a surface erosion phenomenon that produces ultra-fine debris, suggests that histotripsy offers a potential adjunct to conventional shock wave lithotripsy. |
| Starting Page | 342 |
| Ending Page | 345 |
| File Size | 831883 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781457703829 |
| ISSN | 19485727 |
| e-ISBN | 9781457703812 |
| DOI | 10.1109/ULTSYM.2010.5935726 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2010-10-11 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Surface treatment Lithotripsy Ultrasonic imaging Transducers Atmospheric modeling Shock waves Acoustics Cavitation Histotripsy Kidney Stones |
| Content Type | Text |
| Resource Type | Article |
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