NDLI: P3C-7 Microvascular Imaging of Chronic Total Occlusions

Content Provider	IEEE Xplore Digital Library
Author	Thind, A.S. General Leung Munce, N.R. Wright, G.A. Foster, F.S. Graham, J.J.
Copyright Year	2006
Description	Author affiliation: Dept. of Med. Biophys., Toronto Univ., Ont. (Thind, A.S.; General Leung; Munce, N.R.; Wright, G.A.; Foster, F.S.)
Abstract	Chronic total occlusion (CTO) is a condition that occurs when an artery is completely occluded for > 1 month. The ability of ultrasound to detect microvasculature in CTOs is the focus of this study. The development of a superficial porcine femoral model of CTO by percutaneously placing a dissolvable polymer plug in the artery to promote thrombosis has provided a means by which to examine the formation and characteristics of these channels. The arteries, which are ~2-3 mm in diameter, accurately model thrombosis in CTO arteries. Studies have been performed on n = 8 porcine arteries. 3D power Doppler (PD) datasets from the arteries were acquired in vivo using a Vevo 770 system operating at 40 MHz at 1 week and 8 week timepoints. The scanning was performed transcutaneously through ~2 mm of skin to the artery. The formation of microvessels >100 mum in diameter were detected in vivo, as 6 of the 8 arteries self recanalized. At points where PD imaging suggested the presence of microvasculature, PW Doppler profiles were taken showing pulsatile flow rates of ~2 cm/s. The results were correlated with histology. The ability to detect microvessels in vivo with ultrasound suggests a potential method for real time guidance of CTO interventions
Starting Page	2036
Ending Page	2039
File Size	1396719
Page Count	4
File Format	PDF
ISBN	1424402018
ISSN	10510117
DOI	10.1109/ULTSYM.2006.519
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-10-02
Publisher Place	Canada
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Arteries Lesions Ultrasonic imaging Polymers Plugs In vivo Microchannel Angioplasty Biomedical imaging Biophysics
Content Type	Text
Resource Type	Article

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