NDLI: P3D-4 3D Breast Elastography with a Combined Ultrasound/Tomography System

Content Provider	IEEE Xplore Digital Library
Author	Booi, R.C. O'Donnell, M. Knoth, M.M. Xie, H. Rubin, J.M. Hall, A.L. Carson, P.L.
Copyright Year	2006
Description	Author affiliation: Dept. of Radiol., Michigan Univ., Ann Arbor, MI (Booi, R.C.)
Abstract	We have produced high quality strain images in a breast phantom and in 7 human subjects with 3D ultrasound (US) breast elastography using a combined US/tomography system. All radiofrequency (RF) images in this study were acquired using a GE Logiq 9 scanner and a linear 1D array operating at 7.5 MHz on a stand-alone, mammography-mimicking unit. To determine 3D elastography efficacy, a breast phantom (ATS BB-1) was imaged using static compression at 0.5% axial steps up to 2.5% strain over 7-17 elevational steps with slice thicknesses 15-60% of the elevational beamwidth. RF images were correlated using 3D, phase-sensitive speckle tracking algorithms and accumulated, estimated displacements were converted to strain images. Image quality was assessed via correlation coefficient (R) and strain contrast-to-noise ratio (CNR). Results indicated that R remained high and nearly constant (0.96-0.98) for a 0.5% strain step under all conditions. Elevational slice thicknesses of les 30% of the elevational beamwidth sizes produced the highest CNR because thicker slices did not sufficiently meet Nyquist requirements. At slice thicknesses of 35% elevational beamwidth, at least 7 elevational slices were required to meet 3D speckle tracking algorithm spatial requirements in the elevational direction (filter ges kernel = 1 elevational speckle spot). Moving beyond these minimum requirements produced the greatest improvement in CNR with 3D tracking: acquiring elevational planes over 3 speckle spots produced a 90% CNR improvement over 2D analogous. Acquiring up to 4.5 speckle spots (17 elevational planes) increased the CNR by a total of 130%. Additionally, elevational slices off the center axis confirmed on-axis results. Human subject motion was addressed before applying these results in vivo. Volume data acquisition must occur within a patient breath hold (les 10 sec). Thus, all 7 human subjects (1 cancer, 6 fibroadenomas) were imaged using quasistatic elastography as they held their breath. Five axial compression steps were acquired at 0.3-0.7% strain for 7-11 elevational planes with slice thicknesses 30% of the elevational beamwidth (spatially equivalent to 2.0-4.6 speckle spots). When minimal out-of-plane motion was present, there was no significant difference in correlation coefficient values created from 3D and fast (<0.5 sec) 2D acquisition. Thus, potential motion artifacts introduced by 3D data acquisition have been minimized. Of the 7 lesions imaged, 3 were visible on both 3D and 2D and elastograms, with the 3D elastograms depicting $CNR_{epsiv}$ of 7-11% better than 2D. This suggests that 3D elastography on the combined system holds great potential for improving an already clinically valuable imaging technique
Starting Page	2056
Ending Page	2059
File Size	3493467
Page Count	4
File Format	PDF
ISBN	1424402018
ISSN	10510117
DOI	10.1109/ULTSYM.2006.505
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-10-02
Publisher Place	Canada
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Breast Ultrasonic imaging Tomography Capacitive sensors Speckle Humans Radio frequency Imaging phantoms Image coding Data acquisition
Content Type	Text
Resource Type	Article

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