NDLI: LGS shear horizontal SAW devices for biosensor applications

Content Provider	IEEE Xplore Digital Library
Author	Berkenpas, E. Bitla, S. Millard, P. Pereira da Cunha, M.
Copyright Year	2003
Description	Author affiliation: Dept. of Electr. & Comput. Eng., Maine Univ., Orono, ME, USA (Berkenpas, E.)
Abstract	Low cost, highly sensitive biosensors for the selective detection of pathogens in liquids are urgently needed. These sensors can play a major role in limiting the threat of hazardous microbial agents introduced into food and water supplies accidentally or through acts of terrorism. Surface acoustic wave (SAW) sensors utilizing the shear horizontal (SH) mode together with a nucleic acid recognition technique called rolling circle amplification (RCA) represent an attractive technology for this type of application due to reduced acoustic wave attenuation of the SH mode in aqueous environments when compared to generalized SAW. Langasite (LGS) offers high coupling for the SH SAW mode, temperature compensated SH SAW orientations, and high dielectric permittivity aqueous solutions. These properties have been discussed in a previous work by M. Pereira da Cunha et al. (2002). This paper reports on LGS SH SAW delay lines that have been designed and fabricated with a gold shorted delay path as the sensing area, in which biomolecule sensing is performed as a model for the RCA recognition layer. Proteins were sequentially bound to a cysteamine-modified gold surface. With each protein addition, marked changes in the delay line phase were recorded, indicating the functionality of the biosensor as a platform for the RCA layer.
Starting Page	1404
Ending Page	1407
File Size	199771
Page Count	4
File Format	PDF
ISBN	0780379225
DOI	10.1109/ULTSYM.2003.1293166
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2003-10-05
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Surface acoustic wave devices Biosensors Surface acoustic waves Acoustic sensors Acoustic waves Delay lines Gold Proteins Costs Acoustic signal detection
Content Type	Text
Resource Type	Article

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